| Dynamic temporal and spatial regulation of the cdk inhibitor p57(kip2) during embryo morphogenesis. | |
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MedLine Citation:
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PMID: 11677056 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The complete developmental expression pattern of the cyclin dependent kinase inhibitor (CDKI) p57(kip2) has not been reported, here we report a detailed study of the localization of p57(kip2) protein during mouse organogenesis. We show that p57(kip2) is coincident with key stages of differentiation of several organs, some but not all of which are affected in Beckwith-Weidermann syndrome, a human congenital syndrome characterized by foetal overgrowth and childhood tumours. |
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Authors:
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J Westbury; M Watkins; A C Ferguson-Smith; J Smith |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Mechanisms of development Volume: 109 ISSN: 0925-4773 ISO Abbreviation: Mech. Dev. Publication Date: 2001 Nov |
Date Detail:
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Created Date: 2001-10-25 Completed Date: 2002-01-22 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9101218 Medline TA: Mech Dev Country: Ireland |
Other Details:
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Languages: eng Pagination: 83-9 Citation Subset: IM |
Affiliation:
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School of Biological Sciences, University of Birmingham, Edgbaston, B15 2TT, Birmingham, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibody Specificity Cyclin-Dependent Kinase Inhibitor p57 Cyclin-Dependent Kinases / antagonists & inhibitors* Embryonic and Fetal Development Enzyme Inhibitors* Extremities / embryology Gene Expression Regulation, Developmental* Intestines / embryology, metabolism Kidney / embryology, metabolism Lung / embryology, metabolism Mice Mice, Inbred C57BL Morphogenesis Musculoskeletal System / embryology, metabolism Nuclear Proteins / genetics*, metabolism Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Cdkn1c protein, mouse; 0/Cyclin-Dependent Kinase Inhibitor p57; 0/Enzyme Inhibitors; 0/Nuclear Proteins; EC 2.7.11.22/Cyclin-Dependent Kinases |
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