| Dynamic susceptibility contrast MRI with localized arterial input functions. | |
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MedLine Citation:
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PMID: 20432301 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Compared to gold-standard measurements of cerebral perfusion with positron emission tomography using H(2)[(15)O] tracers, measurements with dynamic susceptibility contrast MR are more accessible, less expensive, and less invasive. However, existing methods for analyzing and interpreting data from dynamic susceptibility contrast MR have characteristic disadvantages that include sensitivity to incorrectly modeled delay and dispersion in a single, global arterial input function. We describe a model of tissue microcirculation derived from tracer kinetics that estimates for each voxel a unique, localized arterial input function. Parameters of the model were estimated using Bayesian probability theory and Markov-chain Monte Carlo, circumventing difficulties arising from numerical deconvolution. Applying the new method to imaging studies from a cohort of 14 patients with chronic, atherosclerotic, occlusive disease showed strong correlations between perfusion measured by dynamic susceptibility contrast MR with localized arterial input function and perfusion measured by quantitative positron emission tomography with H(2)[(15)O]. Regression to positron emission tomography measurements enabled conversion of dynamic susceptibility contrast MR to a physiologic scale. Regression analysis for localized arterial input function gave estimates of a scaling factor for quantitation that described perfusion accurately in patients with substantial variability in hemodynamic impairment. |
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Authors:
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John J Lee; G Larry Bretthorst; Colin P Derdeyn; William J Powers; Tom O Videen; Abraham Z Snyder; Joanne Markham; Joshua S Shimony |
Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 63 ISSN: 1522-2594 ISO Abbreviation: Magn Reson Med Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-30 Completed Date: 2010-08-05 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: United States |
Other Details:
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Languages: eng Pagination: 1305-14 Citation Subset: IM |
Copyright Information:
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(c) 2010 Wiley-Liss, Inc. |
Affiliation:
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Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms* Carotid Arteries / pathology*, radionuclide imaging Carotid Artery Diseases / pathology*, radionuclide imaging Contrast Media Gadolinium DTPA / diagnostic use* Humans Image Enhancement / methods* Image Interpretation, Computer-Assisted / methods* Magnetic Resonance Angiography / methods* Reproducibility of Results Sensitivity and Specificity |
| Grant Support | |
ID/Acronym/Agency:
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K08 NS02029/NS/NINDS NIH HHS; K23 HD053212-01A1/HD/NICHD NIH HHS; R01 28497//PHS HHS |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 122795-43-1/gadodiamide; 80529-93-7/Gadolinium DTPA |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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