| Dynamic susceptibility contrast MR imaging: correlation of signal intensity changes with cerebral blood volume measurements. | |
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MedLine Citation:
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PMID: 10713942 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cerebral blood volume (CBV) maps derived from dynamic susceptibility contrast (DSC) magnetic resonance (MR) imaging provide valuable information regarding intracranial micro-hemodynamics and have been helpful in characterizing primary brain tumors and guiding stereotactic biopsy. Another parameter, the maximum signal drop (MSD) during the first pass of intravascular contrast bolus due to T2* effect, can also be measured directly without extensive post-processing and data manipulation. The purpose of our study is to determine whether MSD maps provide information similar to CBV maps in patients presenting with intracranial mass lesions. Twenty-nine patients with various intracranial mass lesions were studied with DSC MR imaging prior to stereotactic biopsy or volumetric resection. Maps of both CBV and MSD are calculated on a pixel-by-pixel basis and displayed as color overlays over the raw images. Relative CBV (rCBV) and MSD (rMSD) values were measured in regions of interest (ROIs) within areas of abnormality and compared. In addition, computer-generated noise was added to the data to estimate the sensitivity of each measurement to noise. The rMSD values were strongly correlated with rCBV values (r = 0.87, P = 0.0001). CBV values were much more sensitive to added noise than MSD values (P < 0.01). MSD maps derived from DSC MR imaging provide information similar to CBV maps in patients with intracranial mass lesions. MSD maps are a simple and reliable indicator of vascularity that can easily be incorporated into routine MR imaging. |
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Authors:
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S Cha; S Lu; G Johnson; E A Knopp |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 11 ISSN: 1053-1807 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2000 Feb |
Date Detail:
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Created Date: 2000-04-05 Completed Date: 2000-04-05 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 114-9 Citation Subset: IM |
Affiliation:
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Department of Radiology, New York University Medical Center, New York 10016, USA. cha@mri.med.nyu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Brain Neoplasms
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blood supply,
pathology* Cerebrovascular Circulation* Contrast Media Echo-Planar Imaging* Female Humans Magnetic Resonance Imaging / methods* Male Middle Aged Signal Processing, Computer-Assisted |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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