| Dynamic spatio-temporal imaging of early reflow in a neonatal rat stroke model. | |
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MedLine Citation:
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PMID: 23047273 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of the study was to better understand blood-flow changes in large arteries and microvessels during the first 15 minutes of reflow in a P7 rat model of arterial occlusion. Blood-flow changes were monitored by using ultrasound imaging with sequential Doppler recordings in internal carotid arteries (ICAs) and basilar trunk. Relative cerebral blood flow (rCBF) changes were obtained by using laser speckle Doppler monitoring. Tissue perfusion was measured with [(14)C]-iodoantipyrine autoradiography. Cerebral energy metabolism was evaluated by mitochondrial oxygen consumption. Gradual increase in mean blood-flow velocities illustrated a gradual perfusion during early reflow in both ICAs. On ischemia, the middle cerebral artery (MCA) territory presented a residual perfusion, whereas the caudal territory remained normally perfused. On reflow, speckle images showed a caudorostral propagation of reperfusion through anastomotic connections, and a reduced perfusion in the MCA territory. Autoradiography highlighted the caudorostral gradient, and persistent perfusion in ventral and medial regions. These blood-flow changes were accompanied by mitochondrial respiration impairment in the ipsilateral cortex. Collectively, these data indicate the presence of a primary collateral pathway through the circle of Willis, providing an immediate diversion of blood flow toward ischemic regions, and secondary efficient cortical anastomoses in the immature rat brain. |
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Authors:
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Pierre-Louis Leger; Philippe Bonnin; Pierre Lacombe; Elisabeth Couture-Lepetit; Sebastien Fau; Sylvain Renolleau; Abdallah Gharib; Olivier Baud; Christiane Charriaut-Marlangue |
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Publication Detail:
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Type: Journal Article Date: 2012-10-10 |
Journal Detail:
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Title: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Volume: 33 ISSN: 1559-7016 ISO Abbreviation: J. Cereb. Blood Flow Metab. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-01-02 Completed Date: 2013-02-21 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 8112566 Medline TA: J Cereb Blood Flow Metab Country: United States |
Other Details:
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Languages: eng Pagination: 137-45 Citation Subset: IM |
Affiliation:
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Sorbonne Paris Cité, INSERM U676, Univ Paris Diderot, Paris, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Autoradiography Blood Flow Velocity / physiology Carotid Artery, Internal / growth & development, physiopathology*, radiography, ultrasonography Cerebrovascular Circulation / physiology* Disease Models, Animal Laser-Doppler Flowmetry Magnetic Resonance Imaging Microvessels / growth & development, physiopathology*, radiography, ultrasonography Middle Cerebral Artery / growth & development, physiopathology*, radiography, ultrasonography Mitochondria / metabolism Oxygen Consumption / physiology Rats Rats, Wistar Reperfusion Injury / metabolism, physiopathology*, radiography, ultrasonography Spatio-Temporal Analysis Stroke / metabolism, physiopathology*, radiography, ultrasonography |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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