Document Detail


Dynamic spatio-temporal imaging of early reflow in a neonatal rat stroke model.
MedLine Citation:
PMID:  23047273     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the study was to better understand blood-flow changes in large arteries and microvessels during the first 15 minutes of reflow in a P7 rat model of arterial occlusion. Blood-flow changes were monitored by using ultrasound imaging with sequential Doppler recordings in internal carotid arteries (ICAs) and basilar trunk. Relative cerebral blood flow (rCBF) changes were obtained by using laser speckle Doppler monitoring. Tissue perfusion was measured with [(14)C]-iodoantipyrine autoradiography. Cerebral energy metabolism was evaluated by mitochondrial oxygen consumption. Gradual increase in mean blood-flow velocities illustrated a gradual perfusion during early reflow in both ICAs. On ischemia, the middle cerebral artery (MCA) territory presented a residual perfusion, whereas the caudal territory remained normally perfused. On reflow, speckle images showed a caudorostral propagation of reperfusion through anastomotic connections, and a reduced perfusion in the MCA territory. Autoradiography highlighted the caudorostral gradient, and persistent perfusion in ventral and medial regions. These blood-flow changes were accompanied by mitochondrial respiration impairment in the ipsilateral cortex. Collectively, these data indicate the presence of a primary collateral pathway through the circle of Willis, providing an immediate diversion of blood flow toward ischemic regions, and secondary efficient cortical anastomoses in the immature rat brain.
Authors:
Pierre-Louis Leger; Philippe Bonnin; Pierre Lacombe; Elisabeth Couture-Lepetit; Sebastien Fau; Sylvain Renolleau; Abdallah Gharib; Olivier Baud; Christiane Charriaut-Marlangue
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Publication Detail:
Type:  Journal Article     Date:  2012-10-10
Journal Detail:
Title:  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism     Volume:  33     ISSN:  1559-7016     ISO Abbreviation:  J. Cereb. Blood Flow Metab.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-02     Completed Date:  2013-02-21     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  8112566     Medline TA:  J Cereb Blood Flow Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  137-45     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Autoradiography
Blood Flow Velocity / physiology
Carotid Artery, Internal / growth & development,  physiopathology*,  radiography,  ultrasonography
Cerebrovascular Circulation / physiology*
Disease Models, Animal
Laser-Doppler Flowmetry
Magnetic Resonance Imaging
Microvessels / growth & development,  physiopathology*,  radiography,  ultrasonography
Middle Cerebral Artery / growth & development,  physiopathology*,  radiography,  ultrasonography
Mitochondria / metabolism
Oxygen Consumption / physiology
Rats
Rats, Wistar
Reperfusion Injury / metabolism,  physiopathology*,  radiography,  ultrasonography
Spatio-Temporal Analysis
Stroke / metabolism,  physiopathology*,  radiography,  ultrasonography
Comments/Corrections

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