Document Detail

Dynamic response of the intracranial system in the conscious dog to papaverine hydrochloride.
MedLine Citation:
PMID:  1006739     Owner:  NLM     Status:  MEDLINE    
The influence of papaverine on the intracranial system of the dog was studied by measuring the pressure-depth-time response for the intact intracranial system, i.e., for the subarachnoid and subpial compartments. This was accomplished by a measurement system which provided an accurate pressure-depth determination and a uniform rate of transducer insertion. Distinct regions of the intracranial system (subarachnoid, transitional, and subpial) were identified from inflections in the pressure response curve. The test parameter, brain relative stiffness (BRS), was obtained by determining the slope of the pressure response values within the subpial region. This parameter is a measure of the "stiffness" or elasticity of bring tissue within the test configuration. A bolus injection of papaverine (1 mg per kilogram, i.v.) caused an increase in the transitional region, a compensatory reduction in the subarachnoid space, and an increase in BRS. It is postulated that at normotensive arterial blood pressure, cerebrovascular expansion caused by papaverine resulted in increased brain tissue elasticity, i.e., an increase in the pressure-depth response for the subpial region. Possible implications for this increase are discussed. Experiments should be conducted in which local blood flow studies are coupled with measurements of brain elastic response.
A Schettini; W W Furniss
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  7     ISSN:  0039-2499     ISO Abbreviation:  Stroke     Publication Date:    1976 Nov-Dec
Date Detail:
Created Date:  1977-02-16     Completed Date:  1977-02-16     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  618-25     Citation Subset:  IM    
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MeSH Terms
Cerebrovascular Circulation / drug effects*
Intracranial Pressure / drug effects*
Models, Neurological
Papaverine / pharmacology*
Subarachnoid Space / drug effects
Subdural Space / drug effects
Time Factors
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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