Document Detail

Dynamic response of blood vessel in acute renal failure.
MedLine Citation:
PMID:  19893084     Owner:  NLM     Status:  MEDLINE    
In this study we postulated that during acute renal failure induced by gentamicin the transient or dynamic response of blood vessels could be affected, and that antioxidants can prevent the changes in dynamic responses of blood vessels. The new approach to ex vivo blood vessel experiments in which not only the end points of vessels response within the time interval is considered, but also dynamics of this response, was used in this paper. Our results confirm the alteration in dynamic response of blood vessels during the change of pressure in gentamicin-treated animals. The beneficial effects of vitamin C administration to gentamicin-treated animals are also confirmed through: lower level of blood urea and creatinine and higher level of potassium. The pressure dynamic responses of isolated blood vessels show a faster pressure change in gentamicin-treated animals (8.07 +/- 1.7 s vs. 5.64 +/- 0.18 s). Vitamin C administration induced slowdown of pressure change back to the control values. The pressure dynamic properties, quantitatively defined by comparative pressure dynamic and total pressure dynamic, confirm the alteration in dynamic response of blood vessels during the change of pressure in gentamicin-treated animals and beneficial effects of vitamin C administration.
Suzana Pantovic; Gvozden Rosic; Zdravko Obradovic; Goran Rankovic; Nenad Stojiljkovic; Mirko Rosic
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  General physiology and biophysics     Volume:  28 Spec No     ISSN:  0231-5882     ISO Abbreviation:  Gen. Physiol. Biophys.     Publication Date:  2009  
Date Detail:
Created Date:  2009-11-06     Completed Date:  2010-04-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8400604     Medline TA:  Gen Physiol Biophys     Country:  Slovakia    
Other Details:
Languages:  eng     Pagination:  87-92     Citation Subset:  IM    
Department of Physiology, Medical Faculty, University of Kragujevac, Svetozara Markovi?a 69, 34 000 Kragujevac, Serbia.
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MeSH Terms
Antioxidants / pharmacology
Ascorbic Acid / pharmacology
Blood Vessels / drug effects,  metabolism*
Creatinine / blood
Gentamicins / toxicity
Kidney / blood supply,  drug effects
Kidney Failure, Acute / blood,  chemically induced,  physiopathology*
Potassium / blood
Sodium / blood
Urea / blood
Reg. No./Substance:
0/Antioxidants; 0/Gentamicins; 50-81-7/Ascorbic Acid; 57-13-6/Urea; 60-27-5/Creatinine; 7440-09-7/Potassium; 7440-23-5/Sodium

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