Document Detail


Dynamic reorganization of metabolic enzymes into intracellular bodies.
MedLine Citation:
PMID:  23057741     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Both focused and large-scale cell biological and biochemical studies have revealed that hundreds of metabolic enzymes across diverse organisms form large intracellular bodies. These proteinaceous bodies range in form from fibers and intracellular foci--such as those formed by enzymes of nitrogen and carbon utilization and of nucleotide biosynthesis--to high-density packings inside bacterial microcompartments and eukaryotic microbodies. Although many enzymes clearly form functional mega-assemblies, it is not yet clear for many recently discovered cases whether they represent functional entities, storage bodies, or aggregates. In this article, we survey intracellular protein bodies formed by metabolic enzymes, asking when and why such bodies form and what their formation implies for the functionality--and dysfunctionality--of the enzymes that comprise them. The panoply of intracellular protein bodies also raises interesting questions regarding their evolution and maintenance within cells. We speculate on models for how such structures form in the first place and why they may be inevitable.
Authors:
Jeremy D O'Connell; Alice Zhao; Andrew D Ellington; Edward M Marcotte
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Annual review of cell and developmental biology     Volume:  28     ISSN:  1530-8995     ISO Abbreviation:  Annu. Rev. Cell Dev. Biol.     Publication Date:  2012  
Date Detail:
Created Date:  2012-10-12     Completed Date:  2013-03-04     Revised Date:  2014-07-10    
Medline Journal Info:
Nlm Unique ID:  9600627     Medline TA:  Annu Rev Cell Dev Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  89-111     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cytoplasmic Granules / enzymology*,  metabolism,  ultrastructure
Escherichia coli / enzymology,  metabolism,  ultrastructure
Escherichia coli Proteins / metabolism
Fungal Proteins / metabolism
Humans
Metabolic Networks and Pathways
Peroxisomes / enzymology
Protein Structure, Quaternary
Protein Transport
Yeasts / enzymology,  metabolism,  ultrastructure
Grant Support
ID/Acronym/Agency:
R01 GM076536/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Escherichia coli Proteins; 0/Fungal Proteins

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