Document Detail


Dynamic proteome in enigmatic preeclampsia: An account of molecular mechanisms and biomarker discovery.
MedLine Citation:
PMID:  22447695     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The coevolution of genomics and proteomics has led to advancements in the field of diagnosis and molecular mechanisms of disease. Proteomics is now stepping into the field of obstetrics, where early diagnosis of pregnancy complication such as preeclampsia (PE) is imperative. PE is a multifactorial disease characterized by hypertension with proteinuria, which is a leading cause of maternal and neonatal morbidity and mortality occurring in 5-7% of pregnancies worldwide. This review discusses the probable molecular mechanisms that lead to PE and summarizes the proteomics research carried out in understanding the pathogenicity of PE, and for identifying the candidate biomarker for diagnosis of the disease.
Authors:
Sheon Mary; Gouri V Patil; Asmita V Kulkarni; Mahesh J Kulkarni; Sadhana R Joshi; Savita S Mehendale; Ashok P Giri
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Proteomics. Clinical applications     Volume:  6     ISSN:  1862-8354     ISO Abbreviation:  Proteomics Clin Appl     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-03-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101298608     Medline TA:  Proteomics Clin Appl     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  79-90     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Affiliation:
Division of Biochemical Sciences, National Chemical Laboratory (CSIR), Pune, Maharashtra, India.
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