| Dynamic profiles of volatile organic compounds in exhaled breath as determined by a coupled PTR-MS/GC-MS study. | |
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MedLine Citation:
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PMID: 20664160 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this phenomenological study we focus on dynamic measurements of volatile organic compounds (VOCs) in exhaled breath under exercise conditions. An experimental setup efficiently combining breath-by-breath analyses using proton transfer reaction mass spectrometry (PTR-MS) with data reflecting the behaviour of major hemodynamic and respiratory parameters is presented. Furthermore, a methodology for complementing continuous VOC profiles obtained by PTR-MS with simultaneous SPME/GC-MS measurements is outlined. These investigations aim at evaluating the impact of breathing patterns, cardiac output or blood pressure on the observed breath concentration and allow for the detection and identification of several VOCs revealing characteristic rest-to-work transitions in response to variations in ventilation or perfusion. Examples of such compounds include isoprene, methyl acetate, butane, DMS and 2-pentanone. In particular, both isoprene and methyl acetate exhibit a drastic rise in concentration shortly after the onset of exercise, usually by a factor of about 3-5 within approximately 1 min of pedalling. These specific VOCs might also be interpreted as potentially sensitive indicators for fluctuations of blood or respiratory flow and can therefore be viewed as candidate compounds for future assessments of hemodynamics, pulmonary function and gas exchange patterns via observed VOC behaviour. |
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Authors:
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J King; P Mochalski; A Kupferthaler; K Unterkofler; H Koc; W Filipiak; S Teschl; H Hinterhuber; A Amann |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-28 |
Journal Detail:
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Title: Physiological measurement Volume: 31 ISSN: 1361-6579 ISO Abbreviation: Physiol Meas Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-12 Completed Date: 2011-01-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9306921 Medline TA: Physiol Meas Country: England |
Other Details:
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Languages: eng Pagination: 1169-84 Citation Subset: IM |
Affiliation:
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University Clinic for Anesthesia, Innsbruck Medical University, Anichstr. 35, A-6020 Innsbruck, Austria. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetone
/
analysis,
chemistry,
isolation & purification Adult Breath Tests / methods* Butadienes / analysis, chemistry, isolation & purification Exhalation* Female Gas Chromatography-Mass Spectrometry / methods* Hemiterpenes / analysis, chemistry, isolation & purification Humans Kinetics Male Noble Gases / metabolism Organic Chemicals / analysis*, chemistry*, isolation & purification Pentanes / analysis, chemistry, isolation & purification Protons* Solid Phase Microextraction Ventilation-Perfusion Ratio Volatilization Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Butadienes; 0/Hemiterpenes; 0/Noble Gases; 0/Organic Chemicals; 0/Pentanes; 0/Protons; 67-64-1/Acetone; 78-79-5/isoprene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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