Document Detail

Dynamic near-infrared spectroscopy measurements in patients with severe sepsis.
MedLine Citation:
PMID:  17414414     Owner:  NLM     Status:  MEDLINE    
This study evaluated near-infrared spectroscopy (NIRS)-derived measurements in hemodynamically stable patients with severe sepsis, as compared with similar measurements in healthy age-matched volunteers. Prospective, preliminary, observational study in a surgical intensive care unit and clinical research center at a university health center. We enrolled 10 patients with severe sepsis and 9 healthy age-matched volunteers. For patients with severe sepsis, we obtained pulmonary artery catheter and laboratory values three times daily for 3 days and oxygen consumption values via metabolic cart once daily for 3 days. For healthy volunteers, we obtained all noninvasive measurements during a single session. We found lower values in patients with severe sepsis (versus healthy volunteers), in tissue oxygen saturation (StO2), in the StO2 recovery slope, in the tissue hemoglobin index, and in the total tissue hemoglobin increase on venous occlusion. Patients with severe sepsis had longer StO2 recovery times and lower NIRS-derived local oxygen consumption values versus healthy volunteers. In our preliminary study, NIRS provides a noninvasive continuous method to evaluate peripheral tissue oxygen metabolism in hemodynamically stable patients with severe sepsis. Further research is needed to demonstrate whether these values apply to broader populations of patients with systemic inflammatory response syndrome, sepsis, severe sepsis, and septic shock.
David E Skarda; Kristine E Mulier; Dean E Myers; Jodie H Taylor; Greg J Beilman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Shock (Augusta, Ga.)     Volume:  27     ISSN:  1073-2322     ISO Abbreviation:  Shock     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-06     Completed Date:  2007-06-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9421564     Medline TA:  Shock     Country:  United States    
Other Details:
Languages:  eng     Pagination:  348-53     Citation Subset:  IM    
Department of Surgery, University of Minnesota, Minneapolis, USA.
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MeSH Terms
Blood Pressure
Hemoglobins / metabolism
Lactic Acid / blood
Middle Aged
Oxygen / metabolism
Sepsis / blood,  metabolism*,  physiopathology
Spectroscopy, Near-Infrared*
Reg. No./Substance:
0/Hemoglobins; 50-21-5/Lactic Acid; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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