| Dynamic multislice helical CT of ameloblastoma and odontogenic keratocyst: correlation between contrast enhancement and angiogenesis. | |
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MedLine Citation:
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PMID: 12488736 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The purpose of this study was to assess whether the enhancement characteristics of dynamic multislice helical CT (MS-CT) could help in the differential diagnosis of ameloblastomas and odontogenic keratocysts. The correlation between enhancement characteristics and immunohistochemical findings, especially with regard to angiogenesis, was also evaluated. METHOD: Dynamic MS-CT was performed in 13 consecutive patients (8 ameloblastoma cases and 5 odontogenic keratocyst cases). The percentage of density increase (Enh%) was measured in dynamic MS-CT images taken during the arterial phase, and microvessel density (MVD) was analyzed using immunohistochemical study with anti-CD31 antibody. The Mann-Whitney U test was used to evaluate the significance of the Enh% or the MVD values between lesion subtypes, and the Spearman correlation coefficient was used to evaluate the correlation between the Enh% and the MVD in ameloblastomas and odontogenic keratocysts. RESULTS: The Enh% in ameloblastomas was significantly higher than that of odontogenic keratocysts (P < 0.005). The MVD of ameloblastomas was also significantly higher than that of odontogenic keratocysts (P < 0.005). The Enh% values for ameloblastomas and odontogenic keratocysts were positively correlated with the respective MVD values (r = 0.92, P < or = 0.000). CONCLUSION: Dynamic MS-CT is useful tool for differentiating between ameloblastomas and odontogenic keratocysts on the basis of the contrast enhancement values of intratumoral vascularities during the arterial phase. Furthermore, the Enh% obtained by dynamic MS-CT is correlated with the MVD in ameloblastomas and odontogenic keratocysts. |
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Authors:
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Katsuhiko Hayashi; Mitsuhiro Tozaki; Masashi Sugisaki; Nahoko Yoshida; Kunihiko Fukuda; Haruyasu Tanabe |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of computer assisted tomography Volume: 26 ISSN: 0363-8715 ISO Abbreviation: J Comput Assist Tomogr Publication Date: 2002 Nov-Dec |
Date Detail:
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Created Date: 2002-12-18 Completed Date: 2003-01-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7703942 Medline TA: J Comput Assist Tomogr Country: United States |
Other Details:
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Languages: eng Pagination: 922-6 Citation Subset: IM |
Affiliation:
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Department of Dentistry, Jikei University School of Medicine, 3-25-8 Nishi-Shinbashi, Minato-ku, Tokyo 105-8461, Japan. katsuh@jikei.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Ameloblastoma / radiography* Diagnosis, Differential Female Humans Immunohistochemistry Jaw Neoplasms / radiography* Male Middle Aged Neovascularization, Pathologic / pathology* Odontogenic Cysts / radiography* Sensitivity and Specificity Tomography, X-Ray Computed / methods* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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