Document Detail

Dynamic modes of the cortical actomyosin gel during cell locomotion and division.
MedLine Citation:
PMID:  16325405     Owner:  NLM     Status:  MEDLINE    
Tight regulation of the contractility of the actomyosin cortex is essential for proper cell locomotion and division. Enhanced contractility leads, for example, to aberrations in the positioning of the mitotic spindle or to anomalous migration modes that allow tumor cells to escape anti-dissemination treatments. Spherical membrane protrusions called blebs occasionally appear during cell migration, cell division or apoptosis. We have shown that the cortex ruptures at sites where actomyosin cortical contractility is increased, leading to the formation of blebs. Here, we propose that bleb formation, which releases cortical tension, can be used as a reporter of cortical contractility. We go on to analyze the implications of spontaneous cortical contractile behaviors on cell locomotion and division and we particularly emphasize that variations in actomyosin contractility can account for a variety of migration modes.
Ewa Paluch; Cécile Sykes; Jacques Prost; Michel Bornens
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-12-01
Journal Detail:
Title:  Trends in cell biology     Volume:  16     ISSN:  0962-8924     ISO Abbreviation:  Trends Cell Biol.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-01-17     Completed Date:  2006-03-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9200566     Medline TA:  Trends Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  5-10     Citation Subset:  IM    
Laboratoire Physicochimie Curie, UMR168 Institut Curie/CNRS, 11 rue Pierre et Marie Curie, 75231 Paris cedex 05, France.
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MeSH Terms
Actomyosin / analysis*,  physiology*,  ultrastructure
Cell Division / physiology*
Cell Membrane / chemistry,  physiology,  ultrastructure
Cell Movement / physiology*
Cell Polarity
Contractile Proteins / analysis,  physiology,  ultrastructure
Cytoplasm / chemistry*,  ultrastructure
Cytoskeletal Proteins / analysis,  physiology,  ultrastructure
Cytoskeleton / chemistry,  physiology,  ultrastructure
Reg. No./Substance:
0/Contractile Proteins; 0/Cytoskeletal Proteins; 0/Gels; 9013-26-7/Actomyosin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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