Document Detail


Dynamic mechanical characterization of biodegradable composites of hydroxyapatite and polylactides.
MedLine Citation:
PMID:  11410890     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The thermo-mechanical analysis of some novel, totally bioactive, three-component composite systems intended for the repair and augmentation of bone has been performed. The composites are composed of hydroxyapatite (HA), particulate reinforced biodegradable polylactic acid (PDLLA), with a second reinforcing phase of semi-crystalline, unidirectional fibers of polylactic acid (PLLA) homopolymer. Dynamic mechanical analysis (DMA) applied small-strain cyclic deformations to simulate physiological loading. The effect of the two fillers on the glass transition temperature of the matrix (Tg-PDLLA) and on the viscoelastic parameters, storage modulus (EI), and tan delta were analyzed. Thermal characterization with differential scanning calorimetry (DSC) was compared to the DMA data. It was established that the addition of HA and/or PLLA fibers increased EI, both below and above Tg-PDLLA. The combination of both reinforcing agents was the most effective. The damping was reduced with the addition of HA alone and in combination with PLLA fibers. Tg-PDLLA was increased by the addition of HA, PLLA fibers, and the combination of the two reinforcing agents. The magnitude of the increase in Tg-PDLLA was similar for both types of reinforcement.
Authors:
S N Nazhat; M Kellomäki; P Törmälä; K E Tanner; W Bonfield
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of biomedical materials research     Volume:  58     ISSN:  0021-9304     ISO Abbreviation:  J. Biomed. Mater. Res.     Publication Date:  2001  
Date Detail:
Created Date:  2001-06-18     Completed Date:  2001-12-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0112726     Medline TA:  J Biomed Mater Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  335-43     Citation Subset:  IM    
Copyright Information:
Copyright 2001 John Wiley & Sons, Inc.
Affiliation:
IRC in Biomedical Materials, Queen Mary University of London, Mile End Road, London, E1 4NS, UK. S.Nazhat@eastman.ucl.uk
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MeSH Terms
Descriptor/Qualifier:
Biocompatible Materials / chemistry*
Durapatite / chemistry*
Polyesters / chemistry*
Surface Properties
Temperature
Chemical
Reg. No./Substance:
0/Biocompatible Materials; 0/Polyesters; 1306-06-5/Durapatite; 26969-66-4/poly(lactide)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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