Document Detail


Dynamic interaction between the tongue and soft palate during obstructive apnea in anesthetized patients with sleep-disordered breathing.
MedLine Citation:
PMID:  12937025     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Little is known about the mechanisms of persistence of obstructive apnea. Structurally, the dorsum of the tongue locates anterior to the soft palate. On the basis of the observation of posterior displacement of the tongue during obstructive apnea, we hypothesized that the dorsum of the tongue pushes the anterior wall of the soft palate posteriorly during inspiratory efforts, maintaining closure at the retropalatal airway. To test this hypothesis, we measured the pressure between dorsum of the tongue and anterior wall of the soft palate (PT&P) during experimentally induced obstructive apneas in anesthetized patients with sleep-disordered breathing. P(T&P) changes during the obstruction significantly depended on collapsibility of the retroglossal airway. Progressive increase in the P(T&P) during obstructive apnea was observed only in patients with highly collapsible retroglossal airways. Significant increase in the P(T&P) during inspiratory effort in accordance with positive deflection pattern of P(T&P) tracing was evident in the patients with highly collapsible retroglossal airways. The results indicate significant dynamic interaction between the tongue and soft palate during both obstructive apnea and each inspiratory effort, possibly maintaining closure at the retropalatal airway.
Authors:
Shiroh Isono; Atsuko Tanaka; Takashi Nishino
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Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2003-08-22
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  95     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-11-05     Completed Date:  2004-07-06     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2257-64     Citation Subset:  IM    
Affiliation:
Department of Anesthesiology (B1 Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan. isonos-chiba@umin.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Adult
Anesthesia
Humans
Male
Middle Aged
Oximetry
Palate, Soft / physiopathology*,  surgery
Pharynx / physiopathology,  surgery
Pressure
Respiratory Mechanics / physiology*
Sleep Apnea, Obstructive / physiopathology*,  surgery
Sleep Disorders / physiopathology*
Tongue / physiopathology*
Uvula / physiopathology,  surgery

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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