| Dynamic in vivo mapping of model moisturiser ingress into human skin by GARfield MRI. | |
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MedLine Citation:
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PMID: 20842757 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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We describe the development of in vivo one-dimensional MRI (profiling) using a GARField (Gradient At Right angles to Field) magnet for the characterisation of side-of-hand human skin. For the first time and in vivo, we report measurements of the NMR longitudinal and transverse relaxation parameters and self-diffusivity of the upper layers of human skin with a nominal spatial resolution better than 10 µm. The results are correlated with in vivo confocal Raman spectroscopy measurements of water concentration and natural moisturiser factors, and discussed in terms of known skin biology and microstructure of the stratum corneum and viable epidermis. The application of model moisturiser solutions to the skin is followed and their dynamics of ingress are characterised using the MRI methodology developed. Selected hydrophilic and lipophilic formulations are studied. The results are corroborated by standard in vivo measurements of transepidermal water loss and hydration status. A further insight into moisturisation mechanisms is gained. The effect of two different penetration enhancers on a commonly used skin care oil is also discussed, and different timescales of oil penetration into the skin are reported depending on the type of enhancer. Copyright © 2010 John Wiley & Sons, Ltd. |
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Authors:
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Elisabetta Ciampi; Michael van Ginkel; Peter J McDonald; Simon Pitts; Eleanor Y M Bonnist; Scott Singleton; Ann-Marie Williamson |
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Publication Detail:
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Type: Journal Article Date: 2010-09-15 |
Journal Detail:
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Title: NMR in biomedicine Volume: 24 ISSN: 1099-1492 ISO Abbreviation: NMR Biomed Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8915233 Medline TA: NMR Biomed Country: England |
Other Details:
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Languages: eng Pagination: 135-44 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 John Wiley & Sons, Ltd. |
Affiliation:
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Unilever Discover, Colworth Science Park, Sharnbrook, Bedford, UK. elisabetta.ciampi@unilever.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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