Document Detail


Dynamic in vitro quantification of bioprosthetic heart valve leaflet motion using structured light projection.
MedLine Citation:
PMID:  11791679     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Quantification of heart valve leaflet deformation during the cardiac cycle is essential in understanding normal and pathological valvular function, as well as in the design of replacement heart valves. Due to the technical complexities involved, little work to date has been performed on dynamic valve leaflet motion. We have developed a novel experimental method utilizing a noncontacting structured laser-light projection technique to investigate dynamic leaflet motion. Using a simulated circulatory loop, a matrix of 150-200 laser light points were projected over the entire leaflet surface. To obtain unobstructed views of the leaflet surface, a stereo system of high-resolution boroscopes was used to track the light points at discrete temporal points during the cardiac cycle. The leaflet surface at each temporal point was reconstructed in three dimensions, and fit using our biquintic hermite finite element approach (Smith et al., Ann. Biomed. Eng. 26:598-611, 2001). To demonstrate our approach, we utilized a bovine pericardial bioprosthetic heart valve, which revealed regions of complex flexural deformation and substantially different shapes during the opening and closing phases. In conclusion, the current method has high spatial and temporal resolution and can reconstruct the entire surface of the cusp simultaneously. Because it is completely noncontacting, this approach is applicable to studies of fatigue and bioreactor technology for tissue engineered heart valves.
Authors:
Iyengar AKS; H Sugimoto; D B Smith; M S Sacks
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of biomedical engineering     Volume:  29     ISSN:  0090-6964     ISO Abbreviation:  Ann Biomed Eng     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2002-01-15     Completed Date:  2002-06-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0361512     Medline TA:  Ann Biomed Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  963-73     Citation Subset:  IM    
Affiliation:
Cardiac Dynamics Laboratory, Children's Hospital of Pittsburgh, Pennsylvania 15261, USA.
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MeSH Terms
Descriptor/Qualifier:
Algorithms
Animals
Bioprosthesis*
Calibration
Cattle
Equipment Design
Heart Valve Prosthesis*
Image Processing, Computer-Assisted
Imaging, Three-Dimensional
Lasers
Models, Cardiovascular*
Movement
Phantoms, Imaging
Photogrammetry / instrumentation*,  methods*
Pulsatile Flow
Surface Properties
Videodisc Recording

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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