Document Detail

Dynamic gadolinium-enhanced MRI in early ischaemia of the proximal femoral epiphysis--a preliminary study.
MedLine Citation:
PMID:  18774363     Owner:  NLM     Status:  MEDLINE    
AIM: To compare the sensitivities of dynamic Gadoteridol (Gd)-enhanced magnetic resonance imaging (MRI) and conventional Gd-enhanced spin-echo (SE) T1-weighted imaging (WI) in the detection of decreased perfusion of early epiphyseal ischaemia, and to determine the contribution of metaphyseal vascularity to physeal perfusion in epiphyseal vascular occlusion by dynamic Gd-enhanced MRI.
MATERIALS AND METHODS: Twenty-eight 2-week-old piglets were divided evenly into four groups: control groups A and B, and ischaemic groups A and B (seven animals in each). In the ischaemic groups, MRI was performed bilaterally on hips in persistent hyperabduction for 30 min. In the control and ischaemic group A the piglets underwent dynamic Gd-enhanced MRI, and in control and ischaemic group B the piglets were subjected to Gd-enhanced SE T1WI.
RESULTS: In ischaemic group A, the enhancement ratio (ER) and enhancement speed (ES) of the various tissues (except the metaphysis) were significantly lower than those in control group A on dynamic Gd-enhanced MRI (p<0.05). However, in ischaemic group B, no significant decrease in the ER of each tissue was found, compared with the ER in control group B as viewed using Gd-enhanced SE T1WI (p>0.05). On dynamic Gd-enhanced MRI, the ER and ES of the physis were less than those of metaphysis in the ischaemic group A (p<0.05); however, the ER and ES of the physis were similar to those of metaphysis in control group A (p>0.05).
CONCLUSION: Dynamic Gd-enhanced MRI is more sensitive than conventional Gd-enhanced SE T1WI in the detection of early epiphyseal ischaemia. Physeal perfusion might be from the metaphysis in epiphyseal vascular occlusion.
X Li; J Qi; L Xia; C Yu; W Peng; X Hu; D Hu; D Feng; J Hu; L Qiu; H Li
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-08-23
Journal Detail:
Title:  Clinical radiology     Volume:  63     ISSN:  1365-229X     ISO Abbreviation:  Clin Radiol     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-08     Completed Date:  2008-11-04     Revised Date:  2013-01-14    
Medline Journal Info:
Nlm Unique ID:  1306016     Medline TA:  Clin Radiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1149-59     Citation Subset:  IM    
Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
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MeSH Terms
Contrast Media
Epiphyses / blood supply,  pathology
Femoral Artery / radiography
Femur Head / blood supply*,  pathology
Heterocyclic Compounds / diagnostic use
Ischemia / diagnosis*,  pathology
Magnetic Resonance Imaging / methods*
Organometallic Compounds / diagnostic use
Sus scrofa
Reg. No./Substance:
0/Contrast Media; 0/Heterocyclic Compounds; 0/Organometallic Compounds; 0199MV609F/gadoteridol

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