Document Detail


Dynamic determinations: patterning the cell behaviours that close the amphibian blastopore.
MedLine Citation:
PMID:  18192174     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We review the dynamic patterns of cell behaviours in the marginal zone of amphibians with a focus on how the progressive nature and the geometry of these behaviours drive blastopore closure. Mediolateral cell intercalation behaviour and epithelial-mesenchymal transition are used in different combinations in several species of amphibian to generate a conserved pattern of circumblastoporal hoop stresses. Although these cell behaviours are quite different and involve different germ layers and tissue organization, they are expressed in similar patterns. They are expressed progressively along presumptive lateral-medial and anterior-posterior axes of the body plan in highly ordered geometries of functional significance in the context of the biomechanics of blastopore closure, thereby accounting for the production of similar patterns of circumblastoporal forces. It is not the nature of the cell behaviour alone, but the context, the biomechanical connectivity and spatial and temporal pattern of its expression that determine specificity of morphogenic output during gastrulation and blastopore closure. Understanding the patterning of these dynamic features of cell behaviour is important and will require analysis of signalling at much greater spatial and temporal resolution than that has been typical in the analysis of patterning tissue differentiation.
Authors:
Ray Keller; David Shook
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Philosophical transactions of the Royal Society of London. Series B, Biological sciences     Volume:  363     ISSN:  0962-8436     ISO Abbreviation:  Philos. Trans. R. Soc. Lond., B, Biol. Sci.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-02-28     Completed Date:  2008-06-03     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  7503623     Medline TA:  Philos Trans R Soc Lond B Biol Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  1317-32     Citation Subset:  IM    
Affiliation:
Department of Biology, University of Virginia, Charlottesville, VA 22904, USA. rek3k@virginia.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Biomechanics
Body Patterning / physiology*
Cell Differentiation / physiology
Cell Movement / physiology*
Gastrula / embryology*
Notochord / embryology
Signal Transduction / physiology*
Species Specificity
Xenopus / embryology*
Grant Support
ID/Acronym/Agency:
R37 HD25594/HD/NICHD NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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