| Dynamic determination and possible mechanism of amino acid transmitter release from rat spinal dorsal horn induced by the venom and a neurotoxin (BmK I) of scorpion Buthus martensi Karsch. | |
| | |
MedLine Citation:
|
PMID: 12121809 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In the present communication, we determined the dynamic release of amino acid transmitters from spinal dorsal horn induced by scorpion Buthus martensi Karsch (BmK) venom and a neurotoxin (BmK I). The results found that glutamate and aspartate release could be evoked significantly within the initial 30 min with the applied doses of either 0.05 and 0.01 mg BmK venom or 0.01 and 0.002 mg BmK I. However, gamma-aminobutyric acid (GABA) release could be largely evoked during the second 30 min by the venom, but not by BmK I. The result suggested that nociceptive afferent fibers could be activated to induce excitatory amino acid release from spinal dorsal horn by nociceptive factors such as BmK I, but the delayed release of GABA might be attributed to the modulating role of some antinociceptive components in the venom. |
| | |
Authors:
|
Xu-Ying Zhang; Jian-Wei Zhang; Bing Chen; Zhan-Tao Bai; Jun Shen; Yong-Hua Ji |
Related Documents
:
|
5684199 - Activity of homocarnosine and other compounds against staphylococcal infections in mice. 21875709 - Immobilization of uricase in langmuir and langmuir-blodgett films of fatty acids and a ... 8568829 - Quinazoline antifolate thymidylate synthase inhibitors: gamma-linked l-d, d-d, and d-l ... 17661369 - The gabaergic-like system in the marine demosponge chondrilla nucula. 9877329 - Inhibition of the synthesis of eicosanoid-like substances in a human oral cancer cell l... 7155349 - Perikaryal cell labeling in the subthalamic nucleus following the injection of 3h-gamma... 5684199 - Activity of homocarnosine and other compounds against staphylococcal infections in mice. 2615569 - Influence of testosterone administration on the biosynthesis of unsaturated fatty acids... 538429 - Analysis of some older scandinavian formulations of 2,4-dichlorophenoxy acetic acid and... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Brain research bulletin Volume: 58 ISSN: 0361-9230 ISO Abbreviation: Brain Res. Bull. Publication Date: 2002 May |
Date Detail:
|
Created Date: 2002-07-17 Completed Date: 2002-10-23 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7605818 Medline TA: Brain Res Bull Country: United States |
Other Details:
|
Languages: eng Pagination: 27-31 Citation Subset: IM |
Copyright Information:
|
Copyright 2002 Elsevier Science Inc. |
Affiliation:
|
Institute of Physiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, PR China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Aspartic Acid / metabolism Glutamic Acid / metabolism Male Microdialysis Neurotransmitter Agents / metabolism* Nociceptors / drug effects*, metabolism* Pain / chemically induced, metabolism Posterior Horn Cells / metabolism* Rats Rats, Sprague-Dawley Scorpion Venoms / pharmacology* gamma-Aminobutyric Acid / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Neurotransmitter Agents; 0/Scorpion Venoms; 0/makatoxin I; 56-12-2/gamma-Aminobutyric Acid; 56-84-8/Aspartic Acid; 56-86-0/Glutamic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cutaneous vascular responses evoked by noxious stimulation in rats with the spinal nerve ligation-in...
Next Document: Chemical preconditioning with 3-nitropropionic acid: lack of induction of neuronal tolerance in gerb...