| Dynamic determination of oxygenation and lung compliance in murine pneumonectomy. | |
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MedLine Citation:
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PMID: 21574875 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thoracic surgical procedures in mice have been applied to a wide range of investigations, but little is known about the murine physiologic response to pulmonary surgery. Using continuous arterial oximetry monitoring and the FlexiVent murine ventilator, the authors investigated the effect of anesthesia and pneumonectomy on mouse oxygen saturation and lung mechanics. Sedation resulted in a dose-dependent decline of oxygen saturation that ranged from 55% to 82%. Oxygen saturation was restored by mechanical ventilation with increased rate and tidal volumes. In the mouse strain studied, optimal ventilatory rates were a rate of 200/minute and a tidal volume of 10 mL/kg. Sustained inflation pressures, referred to as a "recruitment maneuver," improved lung volumes, lung compliance, and arterial oxygenation. In contrast, positive end-expiratory pressure (PEEP) had a detrimental effect on oxygenation; an effect that was ameliorated after pneumonectomy. These results confirm that lung volumes in the mouse are dynamically determined and suggest a threshold level of mechanical ventilation to maintain perioperative oxygen saturation. |
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Authors:
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Barry C Gibney; Grace S Lee; Jan P Houdek; Miao Lin; Lino F Miele; Kenji Chamoto; Moritz A Konerding; Akira Tsuda; Steven J Mentzer |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-05-16 |
Journal Detail:
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Title: Experimental lung research Volume: 37 ISSN: 1521-0499 ISO Abbreviation: Exp. Lung Res. Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-05-18 Completed Date: 2011-09-02 Revised Date: 2012-04-18 |
Medline Journal Info:
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Nlm Unique ID: 8004944 Medline TA: Exp Lung Res Country: England |
Other Details:
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Languages: eng Pagination: 301-9 Citation Subset: IM |
Affiliation:
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Laboratory of Adaptive and Regenerative Biology, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia
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methods Animals Lung / metabolism, physiology* Lung Compliance / physiology* Lung Volume Measurements / methods Mice Mice, Inbred C57BL Oxygen / metabolism* Pneumonectomy / methods* Positive-Pressure Respiration / methods Respiration, Artificial / methods Tidal Volume / physiology Total Lung Capacity / physiology |
| Grant Support | |
ID/Acronym/Agency:
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HL47078/HL/NHLBI NIH HHS; HL75426/HL/NHLBI NIH HHS; HL94567/HL/NHLBI NIH HHS; R01 HL047078-08/HL/NHLBI NIH HHS; R01 HL075426-02/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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