Document Detail


Dynamic cross-talk between cells and the extracellular matrix in the testis.
MedLine Citation:
PMID:  15351968     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the seminiferous tubule of the mammalian testis, one type A1 spermatogonium (diploid, 2n) divides and differentiates into 256 spermatozoa (haploid, n) during spermatogenesis. To complete spermatogenesis and produce approximately 150 x 10(6) spermatozoa each day in a healthy man, germ cells must migrate progressively across the seminiferous epithelium yet remain attach to the nourishing Sertoli cells. This active cell migration process involves precisely controlled restructuring events at the tight (TJ) and anchoring junctions at the cell-cell interface. While the hormonal events that regulate spermatogenesis by follicle-stimulating hormone and testosterone from the pituitary gland and Leydig cells, respectively, are known, less is known about the mechanism(s) that regulates junction restructuring during germ cell movement in the seminiferous epithelium. The relative position of tight (TJs) and anchoring junctions in the testis is of interest. Sertoli cell TJs that constitute the blood-testis barrier (BTB) are present side by side with anchoring junctions and are adjacent to the basement membrane. This intimate physical association with the TJs, the anchoring junctions and the basement membrane (a modified form of extracellular matrix, ECM) suggests a role for the ECM in the junction dynamics of the testis. Indeed, evidence is accumulating that ECM proteins are crucial to Sertoli cell TJ dynamics. In this review, we discuss the pivotal role of tumor necrosis factor alpha (TNFalpha) on BTB dynamics via its effects on the homeostasis of ECM proteins. In addition, discussion will also be focused on the novel findings regarding the role of non-basement-membrane-associated ECM proteins and components of focal adhesion (a cell-matrix anchoring junction type) in the regulation of junction dynamics in the testis.
Authors:
Michelle K Y Siu; C Yan Cheng
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  BioEssays : news and reviews in molecular, cellular and developmental biology     Volume:  26     ISSN:  0265-9247     ISO Abbreviation:  Bioessays     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-09-07     Completed Date:  2004-09-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8510851     Medline TA:  Bioessays     Country:  United States    
Other Details:
Languages:  eng     Pagination:  978-92     Citation Subset:  IM    
Affiliation:
Population Council, Center for Biomedical Research, New York, New York 10021, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Adhesion
Cell Communication
Collagen Type IV / metabolism
Extracellular Matrix / metabolism*
Humans
Male
Models, Biological
Rats
Seminiferous Tubules / metabolism
Sertoli Cells / metabolism
Spermatozoa / metabolism
Testis / enzymology,  metabolism*
Tight Junctions
Tumor Necrosis Factor-alpha / metabolism
Grant Support
ID/Acronym/Agency:
U01 HD45908/HD/NICHD NIH HHS; U54 HD29990/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Collagen Type IV; 0/Tumor Necrosis Factor-alpha

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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