Document Detail


Dynamic contrast-enhanced ultrasonography (DCE-US) and anti-angiogenic treatments.
MedLine Citation:
PMID:  21276407     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Dynamic contrast-enhanced ultrasonography (DCE-US) is a current functional imaging technique enabling a quantitative assessment of tumor perfusion using raw linear data. DCE-US allows calculating several parameters as slope of wash-in or area under the curve representing, respectively, blood flow or blood volume. Decrease of vascularization can easily be detected in responders after 1 or 2 weeks of anti-angiogenic treatment for gastrointestinal stromal tumors (GIST), renal cell carcinoma (RCC), and hepatocellular carcinoma (HCC) and is correlated with progression-free survival and overall survival in RCC or HCC. DCE-US is supported by the French National Cancer Institute (INCa), which is currently studying the technique in metastatic breast cancer, melanoma, colon cancer, gastrointestinal stromal tumors and renal cell carcinoma, as well as in primary hepatocellular carcinoma, to establish the optimal perfusion parameters and timing for quantitative anticancer efficacy assessments. Currently 479 patients are included in 19 centers and the preliminary results on 400 patients with 1096 DCE-US demonstrated that the area under the curve (AUC) quantified at 1 month could be a robust parameter to predict response at 6 months.
Authors:
Nathalie Lassau; Linda Chami; Mohamed Chebil; Baya Benatsou; Sophie Bidault; Elizabeth Girard; Ghassen Abboud; Alain Roche
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Discovery medicine     Volume:  11     ISSN:  1944-7930     ISO Abbreviation:  Discov Med     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101250006     Medline TA:  Discov Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  18-24     Citation Subset:  IM    
Affiliation:
Ultrasonography Unit, Imaging Department, Institut Gustave Roussy, Villejuif, 94805, France. Nathalie.Lassau@igr.fr.
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