| Dynamic contrast-enhanced perfusion MR imaging measurements of endothelial permeability: differentiation between atypical and typical meningiomas. | |
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MedLine Citation:
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PMID: 13679270 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: The measurement of relative cerebral blood volume (rCBV) and the volume transfer constant (K(trans)) by means of dynamic contrast-enhanced (DCE) perfusion MR imaging (pMRI) can be useful in characterizing brain tumors. The purpose of our study was to evaluate the utility of these measurements in differentiating typical meningiomas and atypical meningiomas. METHODS: Fifteen patients with pathologically confirmed typical meningiomas and seven with atypical meningiomas underwent conventional imaging and DCE pMRI before resection. rCBV measurements were calculated by using standard intravascular indicator dilution algorithms. K(trans) was calculated from the same DCE pMRI data by using a new pharmacokinetic modeling (PM) algorithm. Results were compared with pathologic findings. RESULTS: Mean rCBV was 8.02 +/- 4.74 in the 15 typical meningiomas and 10.50 +/- 2.1 in the seven atypical meningiomas. K(trans) was 0.0016 seconds(-1) +/- 0.0012 in the typical group and 0.0066 seconds(-1) +/- 0.0026 in the atypical group. The difference in K(trans) was statistically significant (P <.01, Student t test). Other parameters generated with the PM algorithm (plasma volume, volume of the extravascular extracellular space, and flux rate constant) were not significantly different between the two tumor types. CONCLUSION: DCE pMRI may have a role in the prospective characterization of meningiomas. Specifically, the measurement of K(trans) is of use in distinguishing atypical meningiomas from typical meningiomas. |
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Authors:
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Stanley Yang; Meng Law; David Zagzag; Hope H Wu; Soonmee Cha; John G Golfinos; Edmond A Knopp; Glyn Johnson |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: AJNR. American journal of neuroradiology Volume: 24 ISSN: 0195-6108 ISO Abbreviation: AJNR Am J Neuroradiol Publication Date: 2003 Sep |
Date Detail:
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Created Date: 2003-09-18 Completed Date: 2004-01-08 Revised Date: 2008-02-14 |
Medline Journal Info:
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Nlm Unique ID: 8003708 Medline TA: AJNR Am J Neuroradiol Country: United States |
Other Details:
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Languages: eng Pagination: 1554-9 Citation Subset: IM |
Affiliation:
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Department of Radiology/Division of Neuroradiology, New York University Medical Center, NY, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Algorithms Blood Volume / physiology Blood-Brain Barrier / physiology Capillary Permeability / physiology* Contrast Media / administration & dosage Echo-Planar Imaging / methods Endothelium, Vascular / pathology, physiopathology*, surgery Female Humans Image Enhancement / methods* Image Processing, Computer-Assisted / methods* Indicator Dilution Techniques* Magnetic Resonance Angiography / methods* Male Meningeal Neoplasms / blood supply*, diagnosis*, pathology, surgery Meningioma / blood supply*, diagnosis*, pathology, surgery Middle Aged Prognosis Regional Blood Flow / physiology Retrospective Studies Sensitivity and Specificity |
| Grant Support | |
ID/Acronym/Agency:
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R01CA09399/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media |
| Comments/Corrections | |
Comment In:
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AJNR Am J Neuroradiol. 2003 Sep;24(8):1499-500
[PMID:
13679258
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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