| Dynamic contrast-enhanced magnetic resonance imaging and blood oxygenation level-dependent magnetic resonance imaging for the assessment of changes in tumor biology with treatment. | |
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MedLine Citation:
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PMID: 22043053 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Functional magnetic resonance imaging (MRI) techniques are rapidly gaining importance as methods of exploring the pathophysiological properties of breast carcinomas. In the neoadjuvant setting where the primary tumor remains in situ, functional MRI is able to noninvasively evaluate microenvironmental features such as blood flow and oxygenation. Dynamic contrast-enhanced MRI provides information on tumor vascularity with evidence suggesting a role in predicting response to neoadjuvant chemotherapy. The spatial heterogeneity of response to anti-angiogenic and vascular disrupting agents can also be depicted. There is preliminary data supporting blood oxygenation level-dependent MRI as a potential marker of tumor oxygenation, with the ability to characterize tissue oxygenation changes with neoadjuvant chemotherapy. Additionally, advanced MR sequences such as diffusion-weighted MRI and MR spectroscopy have the potential to provide information relating to cellularity and metabolism, respectively. |
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Authors:
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Sonia P Li; Anwar R Padhani; Andreas Makris |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the National Cancer Institute. Monographs Volume: 2011 ISSN: 1745-6614 ISO Abbreviation: J. Natl. Cancer Inst. Monographs Publication Date: 2011 |
Date Detail:
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Created Date: 2011-11-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9011255 Medline TA: J Natl Cancer Inst Monogr Country: United States |
Other Details:
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Languages: eng Pagination: 103-7 Citation Subset: IM |
Affiliation:
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Academic Oncology Unit, Mount Vernon Cancer Centre, Rickmansworth Rd, Northwood, Middlesex HA62RN, UK. amakris@nhs.net. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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