| Dynamic contrast-enhanced magnetic resonance imaging of human cervical carcinoma xenografts: pharmacokinetic analysis and correlation to tumor histomorphology. | |
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MedLine Citation:
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PMID: 20656365 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: Biomarkers that can predict the outcome of treatment accurately are needed for treatment individualization in advanced carcinoma of the uterine cervix. The potential of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) was investigated in the present preclinical study. MATERIALS AND METHODS: CK-160 and TS-415 human cervical carcinoma xenografts were subjected to DCE-MRI at 1.5T using a spatial resolution of 0.23×0.47×2.0mm(3). Parametric images of K(trans) (the volume transfer constant of Gd-DTPA) and v(e) (the extravascular extracellular volume fraction) were produced by pharmacokinetic analysis of the DCE-MRI data and compared with the histomorphology of the imaged tissue. RESULTS: Analysis of small homogeneous tumor regions showed that K(trans), but not v(e), differed significantly between parenchymal tissue, connective tissue, and necrotic tissue, consistent with the vascularity of these compartments. However, strong correlations between K(trans) and the fractional volume of the compartments could not be detected for larger tumor regions, primarily because the majority of the voxels represented a chaotic mixture of parenchymal, connective, and necrotic tissue. CONCLUSION: The potential of DCE-MRI in providing detailed information on the histomorphology of cervical carcinoma is limited, mainly because the tumor tissue shows significant morphological heterogeneity at the subvoxel level. |
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Authors:
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Christine Ellingsen; Tormod A M Egeland; Kanthi Galappathi; Einar K Rofstad |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-23 |
Journal Detail:
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Title: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology Volume: 97 ISSN: 1879-0887 ISO Abbreviation: Radiother Oncol Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8407192 Medline TA: Radiother Oncol Country: Ireland |
Other Details:
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Languages: eng Pagination: 217-24 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital, Norway. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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