| Dynamic contrast-enhanced brain perfusion imaging: technique and clinical applications. | |
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MedLine Citation:
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PMID: 11138635 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Magnetic resonance (MR) and computed tomographic (CT) perfusion imaging are evolving noninvasive imaging techniques that, unlike conventional MR and CT angiographic methods, can be used to evaluate capillary level tissue perfusion. These techniques can provide early, highly accurate delineation of ischemic tissue, allowing the underlying hemodynamic disturbances of disorders such as stroke and vasospasm to be further analyzed, as well as defining abnormal regions of blood pool in brain tumors. Because MR perfusion (MRP) and CT perfusion (CTP) imaging can assess physiologic parameters such as cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time (MTT), they offer additional data that can be useful in the detection and characterization of entities such as tumor, infection, inflammation, and infarction, which all can have similar appearances on both contrast and noncontrast enhanced conventional CT and MR images. They can also facilitate the further evaluation of processes such as early dementia, psychiatric illnesses, and migraine headaches, which may appear normal on routine CT and MR imaging. MRP and CTP might also be of value in distinguishing residual or recurrent tumor from treatment effects such as radiation-induced necrosis. This article reviews the background principles, scanning techniques, and clinical applications of noninvasive cerebral perfusion imaging. |
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Authors:
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F G Aksoy; M H Lev |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Seminars in ultrasound, CT, and MR Volume: 21 ISSN: 0887-2171 ISO Abbreviation: Semin. Ultrasound CT MR Publication Date: 2000 Dec |
Date Detail:
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Created Date: 2001-01-02 Completed Date: 2001-02-15 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8504689 Medline TA: Semin Ultrasound CT MR Country: United States |
Other Details:
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Languages: eng Pagination: 462-77 Citation Subset: IM |
Affiliation:
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Department of Radiology, Massachusetts General Hospital, Boston 02116, USA. fgaksoy@partners.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Brain
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blood supply*,
metabolism,
pathology*,
radiography Brain Diseases / diagnosis* Brain Neoplasms / diagnosis Cerebrovascular Circulation* Contrast Media Humans Magnetic Resonance Imaging / methods* Regional Blood Flow Stroke / diagnosis Tomography, X-Ray Computed / methods* |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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