| Dynamic contrast-enhanced T2*-weighted MR imaging: a peritumoral brain oedema study. | |
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MedLine Citation:
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PMID: 19054561 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: Glioma and meningioma are the two most common types of primary brain tumor. The aim of the present study was to analyze, using dynamic susceptibility contrast MR perfusion imaging, the effect of angiogenesis on peritumoral tissue. METHODS: In this prospective study, conducted from December 2003 to March 2005, out of 18 patients recruited, 12 were included (six with meningioma, six with glioblastoma). Using rates of maximum signal drop (MSD), we drew regions of interest (ROI) starting near the lesion, and gradually moving outwards to areas of distant edema in axial and sagittal planes at 10, 20 and 30 mm from the tumor. We also drew ROI on the contralateral brain white matter to obtain a normal baseline for comparison (relative MSD; rMSD). RESULTS: In regions of peritumoral T2 hypersignals, we observed a decrease in rMSD with distance from glioblastoma due to reduced angiogenesis, and an increase in rMSD with distance from meningioma, probably due to a reduced mass effect. CONCLUSION: In our study, dynamic susceptibility contrast MR perfusion imaging, using MSD as a parameter, revealed differences between meningioma and glioblastoma peritumoral tissue due to changes in angiogenesis. |
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Authors:
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P Lehmann; J-N Vallée; G Saliou; P Monet; A Bruniau; A Fichten; G De Marco |
Publication Detail:
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Type: Comparative Study; Journal Article Date: 2008-12-02 |
Journal Detail:
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Title: Journal of neuroradiology. Journal de neuroradiologie Volume: 36 ISSN: 0150-9861 ISO Abbreviation: J Neuroradiol Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-05-04 Completed Date: 2009-08-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7705086 Medline TA: J Neuroradiol Country: France |
Other Details:
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Languages: eng Pagination: 88-92 Citation Subset: IM |
Affiliation:
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Amiens university-hospital, 1, place Victor-Pauchet, 80054 Amiens cedex 1, France. lehmann.pierre@chu-amiens.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Brain / pathology* Brain Edema / etiology, pathology* Brain Mapping / methods Brain Neoplasms / complications, diagnosis, pathology* Diagnostic Imaging Female Glioma / complications, diagnosis, pathology* Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging / methods* Male Meningeal Neoplasms / complications, diagnosis, pathology* Meningioma / complications, diagnosis, pathology* Middle Aged Prospective Studies Signal Processing, Computer-Assisted |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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