| Dynamic contrast-enhanced MRI using macromolecular contrast media for monitoring the response to isolated limb perfusion in experimental soft-tissue sarcomas. | |
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MedLine Citation:
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PMID: 15480945 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of this study was to evaluate the potential of dynamic contrast-enhanced MRI for quantitative characterization of tumor microvessels and to assess the microvascular changes in response to isolated limb perfusion with TNF-alpha and melphalan. Dynamic contrast-enhanced MRI was performed in an experimental cancer model, using a macromolecular contrast medium, albumin-(Gd-DTPA)45. Small fragments of BN 175, a soft-tissue sarcoma, were implanted in 11 brown Norway (BN) rats. Animals were assigned randomly to a control (Haemaccel) or drug-treated group (TNF-alpha/melphalan). MRI was performed at baseline and 24 h after ILP. The transendothelial permeability (K(PS)) and the fractional plasma volume (fPV) were estimated from the kinetic analysis of MR data using a two-compartment bi-directional model. K(PS) and fPV decreased significantly in the drug-treated group compared to baseline (p<0.05). In addition, K(PS) post therapy was significantly lower (p<0.05) in the drug-treated group than in the control group. There was no significant difference in fPV between the drug-treated and the control group after therapy. Tumor microvascular changes in response to isolated limb perfusion can be determined after 24 h by dynamic contrast-enhanced MRI. The data obtained in this experimental model suggest possible applications in the clinical setting, using the appropriate MR contrast agents. |
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Authors:
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A Preda; P A Wielopolski; T L M Ten Hagen; M van Vliet; J F Veenland; G Ambagtsheer; S T van Tiel; M W Vogel; A M M Eggermont; G P Krestin; C F van Dijke |
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Publication Detail:
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Type: Evaluation Studies; Journal Article Date: 2004-10-10 |
Journal Detail:
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Title: Magma (New York, N.Y.) Volume: 17 ISSN: 0968-5243 ISO Abbreviation: MAGMA Publication Date: 2004 Dec |
Date Detail:
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Created Date: 2005-02-10 Completed Date: 2005-06-16 Revised Date: 2006-04-24 |
Medline Journal Info:
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Nlm Unique ID: 9310752 Medline TA: MAGMA Country: Germany |
Other Details:
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Languages: eng Pagination: 296-302 Citation Subset: IM |
Affiliation:
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Department of Radiology, Erasmus MC-University Medical Center Rotterdam, Dr. Molewaterplein 40, 3015, GD, Rotterdam, The Netherlands. a.huurman@erasmusmc.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Albumins
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diagnostic use* Animals Antineoplastic Combined Chemotherapy Protocols / administration & dosage Chemotherapy, Cancer, Regional Perfusion / methods Contrast Media* Extremities / blood supply Gadolinium DTPA / diagnostic use* Image Enhancement / methods* Macromolecular Substances / diagnostic use Magnetic Resonance Imaging / methods* Male Melphalan / administration & dosage* Prognosis Rats Rats, Inbred BN Sarcoma, Experimental / diagnosis*, drug therapy* Treatment Outcome Tumor Necrosis Factor-alpha / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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0/Albumins; 0/Contrast Media; 0/Macromolecular Substances; 0/Tumor Necrosis Factor-alpha; 0/albumin-(gadolinium-DTPA); 148-82-3/Melphalan; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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