Document Detail

Dynamic contrast-enhanced MR imaging of the upper abdomen: enhancement properties of gadobutrol, gadolinium-DTPA-polylysine, and gadolinium-DTPA-cascade-polymer.
MedLine Citation:
PMID:  7808263     Owner:  NLM     Status:  MEDLINE    
The enhancement properties of gadobutrol (40 and 80 mumol/kg body weight, 550 daltons), gadolinium-DTPA-polylysine (20 mumol/kg body weight, 53,000 daltons) and gadolinium-DTPA-cascade-polymer (20 mumol/kg body weight, < 30,000 Daltons) were investigated in abdominal MR imaging using a pig model (n = 24). Signal intensities before and after contrast media application were assessed using a fast single slice FLASH sequence. Measurements were made every 4 s within the first 116 s, every minute between 4 and 10 min and after 15, 20, 30, 40, 50, 60, 90, and 120 min after contrast media injection. Injection of gadobutrol resulted in typical signal intensity curves characterizing it as an extracellular agent similar to gadopentetate dimeglumine. Significant enhancement was found in all tissues except the trunk muscles when the lower dose was administered. Gadolinium-DTPA-polylysine injection resulted also in significant enhancement of the liver, the pancreas, and the renal cortex, but not of the trunk muscle, reflecting its blood pool properties known also from other macromolecular contrast agents. The signal intensity curves obtained after gadolinium-DTPA-cascade-polymer injection were similar to those obtained after polylysine injection, stressing the blood pool character of this new type of blood pool agent.
G Adam; J Neuerburg; E Spüntrup; A Mühler; K Scherer; R W Günther
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine     Volume:  32     ISSN:  0740-3194     ISO Abbreviation:  Magn Reson Med     Publication Date:  1994 Nov 
Date Detail:
Created Date:  1995-02-02     Completed Date:  1995-02-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8505245     Medline TA:  Magn Reson Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  622-8     Citation Subset:  IM    
Department of Diagnostic Radiology, University of Technology, Aachen, Germany.
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MeSH Terms
Abdomen / anatomy & histology*
Abdominal Muscles / anatomy & histology
Contrast Media* / administration & dosage
Gadolinium / administration & dosage,  blood,  diagnostic use*
Gadolinium DTPA*
Image Enhancement / methods*
Kidney Cortex / anatomy & histology
Liver / anatomy & histology
Magnetic Resonance Imaging / methods*
Models, Biological
Organometallic Compounds / administration & dosage,  blood,  diagnostic use*
Pancreas / anatomy & histology
Pentetic Acid / administration & dosage,  analogs & derivatives*,  diagnostic use
Polylysine / administration & dosage,  analogs & derivatives*,  blood,  diagnostic use
Polymers / administration & dosage,  diagnostic use*
Time Factors
Reg. No./Substance:
0/Contrast Media; 0/Organometallic Compounds; 0/Polymers; 0/gadolinium-diethylenetriaminepentaacetic acid-cascade-polymer; 0/polylysine-(Gd-DTPA); 138071-82-6/gadobutrol; 25104-18-1/Polylysine; 67-43-6/Pentetic Acid; 7440-54-2/Gadolinium; 80529-93-7/Gadolinium DTPA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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