| Dynamic contrast-enhanced MR imaging to assess physiologic variations of myometrial perfusion. | |
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MedLine Citation:
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PMID: 19820949 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To prospectively evaluate the ability of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to assess physiological microvascular states in normal myometrium. MATERIALS AND METHODS: Eighty-five women (62 women of reproductive age, 23 postmenopausal) undergoing DCE-MRI of the pelvis were included. Microvascular parameters for the inner and outer myometrium were analysed using a pharmacokinetic model. These parameters were tissue blood flow (F), blood volume fraction (V(b)), permeability-surface area product (PS), interstitial volume fraction (V(e)) and lag time (Dt). RESULTS: In the women of reproductive age, the inner myometrium displayed higher F and PS, lower V(b) and V(e), and longer Dt than the outer myometrium (p = 0.02, p = 0.01, p = 0.005, p = 0.03 and p = 0.01, respectively). The inner myometrium presented microvascular variations during the menstrual cycle with a pre-ovulatory peak followed by a fall reaching a nadir of F and V(b) about 4 days after ovulation. Compared with women of reproductive age, in the postmenopausal state, F and V(b) decreased in the outer myometrium, while PS, V(e) and Dt increased (p < 0.0001, p = 0.001, p = 0.001, p = 0.03 and p = 0.0004, respectively). CONCLUSION: DCE-MRI is a non-invasive technique that can measure variations of myometrial microcirculation, and thereby be potentially useful to help characterize the role and states of the myometrium in assisted reproductive therapy. |
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Authors:
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Isabelle Thomassin-Naggara; Daniel Balvay; Charles A Cuenod; Emile Dara?; Claude Marsault; Marc Bazot |
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Publication Detail:
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Type: Journal Article Date: 2009-10-10 |
Journal Detail:
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Title: European radiology Volume: 20 ISSN: 1432-1084 ISO Abbreviation: Eur Radiol Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-10 Completed Date: 2010-06-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9114774 Medline TA: Eur Radiol Country: Germany |
Other Details:
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Languages: eng Pagination: 984-94 Citation Subset: IM |
Affiliation:
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Department of Radiology, H?pital Tenon, Assistance Publique-H?pitaux de Paris, Paris, France. isabellethomassin@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Algorithms* Blood Flow Velocity Computer Simulation Contrast Media / pharmacokinetics Feasibility Studies Female Gadolinium / diagnostic use*, pharmacokinetics* Humans Image Enhancement / methods Image Interpretation, Computer-Assisted / methods* Kinetics Magnetic Resonance Angiography / methods* Menstrual Cycle / metabolism* Metabolic Clearance Rate Middle Aged Models, Biological Myometrium / blood supply, physiology* Reproducibility of Results Sensitivity and Specificity Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 7440-54-2/Gadolinium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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