| Dynamic contrast-enhanced CT in patients treated with sorafenib and erlotinib for non-small cell lung cancer: a new method of monitoring treatment? | |
| | |
MedLine Citation:
|
PMID: 20625738 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
OBJECTIVE: We investigated the feasibility of serial dynamic contrast-enhanced computed tomography (DCE-CT) in patients with advanced/metastatic non-small cell lung cancer (NSCLC) receiving anti-angiogenic (sorafenib) and anti-EGFR (erlotinib) treatment, and correlated tumour blood flow (BF) with treatment outcome. METHODS: DCE-CTs were performed at baseline and 3 and 6 weeks after starting treatment. Tumour BF, calculated with the maximum slope method, and percentage change were measured in 23 patients (14 male; median age 59 years). Tumour BF was compared at baseline and weeks 3 and 6; the relation with RECIST/Crabb response and progression-free survival (PFS) was assessed. RESULTS: Mean tumour perfusion decreased from 39.2 ml/100 g/min at baseline to 15.1 ml/100 g/min at week 3 (p < 0.001) and 9.4 ml/100 g/min at week 6 (p < 0.001). Tumour perfusion was lower in RECIST and Crabb responders versus non-responders at week 3 (4.2 versus 17.7 ml/100 g/min, p = 0.03) and week 6 (0 versus 13.4 ml/100 g/min, p = 0.04). Patients with a decrease larger than the median at week 6 tended to have a longer PFS (7.1 versus 5.7 months, p = 0.06). CONCLUSION: Serial DCE-CTs are feasible in patients with NSCLC and demonstrated a significant decrease in tumour BF following sorafenib/erlotinib therapy. Early changes in tumour BF correlated with objective response and showed a trend towards longer PFS. |
| | |
Authors:
|
Joline S W Lind; Martijn R Meijerink; Anne-Marie C Dingemans; Cornelis van Kuijk; Michel C Ollers; Dirk de Ruysscher; Pieter E Postmus; Egbert F Smit |
Related Documents
:
|
12846498 - Treatment of neuroendocrine tumours in adults with 131i-mibg therapy. 9743308 - Tumour hypoxia and vascular density as predictors of metastasis in squamous cell carcin... 8544088 - Systemic mycosis caused by a new cladophialophora species. 4036458 - Bilateral urological tumours. 22328268 - Caudate lobe resection with major hepatectomy for central cholangiocarcinoma: is it of ... 19920198 - Intrinsic gene expression profiles of gliomas are a better predictor of survival than h... |
Publication Detail:
|
Type: Journal Article Date: 2010-07-13 |
Journal Detail:
|
Title: European radiology Volume: 20 ISSN: 1432-1084 ISO Abbreviation: Eur Radiol Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-11-11 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9114774 Medline TA: Eur Radiol Country: Germany |
Other Details:
|
Languages: eng Pagination: 2890-8 Citation Subset: IM |
Affiliation:
|
Department of Pulmonary Diseases, VU University Medical Center, Amsterdam, the Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of CT scan protocols on x-ray-induced DNA double-strand breaks in blood lymphocytes of patien...
Next Document: Hydrocephalus and aquaporins: lessons learned from the bench.