| Dynamic, contrast-enhanced CT of human brain tumors: quantitative assessment of blood volume, blood flow, and microvascular permeability: report of two cases. | |
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MedLine Citation:
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PMID: 12006286 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We present two patients with metastatic brain tumors who underwent dynamic contrast-enhanced CT that yielded estimates of blood volume, blood flow, and microvascular permeability. For one patient, these CT-based quantifications were compared with contrast-enhanced MR-based assessments of fractional blood volume and permeability. Regional blood volume heterogeneity patterns were consistent between both CT- and MR imaging-based mapping. Permeability variations across the tumor, however, were less consistent, perhaps because of differences between ionic and non-ionic contrast agents. The advantages of dynamic contrast-enhanced CT in comparison with dynamic, contrast-enhanced MR imaging for microvascular quantifications are its availability and lower costs, applicability in the presence of MR imaging contraindications, and potentially more accurate analyses. The disadvantages are its limited anatomic coverage, radiation exposure, and the need for injection of a contrast agent. |
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Authors:
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Heidi C Roberts; Timothy P L Roberts; Ting-Yim Lee; William P Dillon |
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Publication Detail:
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Type: Case Reports; Comparative Study; Journal Article |
Journal Detail:
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Title: AJNR. American journal of neuroradiology Volume: 23 ISSN: 0195-6108 ISO Abbreviation: AJNR Am J Neuroradiol Publication Date: 2002 May |
Date Detail:
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Created Date: 2002-05-13 Completed Date: 2002-06-11 Revised Date: 2008-02-14 |
Medline Journal Info:
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Nlm Unique ID: 8003708 Medline TA: AJNR Am J Neuroradiol Country: United States |
Other Details:
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Languages: eng Pagination: 828-32 Citation Subset: IM |
Affiliation:
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Department of Radiology, University of California, San Francisco, San Francisco, CA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
/
blood supply,
diagnosis,
radiography*,
secondary Aged Blood Volume Brain Neoplasms / blood supply, diagnosis, radiography* Capillary Permeability Contrast Media* Female Humans Magnetic Resonance Imaging Melanoma / blood supply, diagnosis, radiography*, secondary Microcirculation Middle Aged Tomography, X-Ray Computed* |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media |
| Comments/Corrections | |
Comment In:
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AJNR Am J Neuroradiol. 2002 May;23(5):746-7
[PMID:
12006270
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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