| Dynamic computed tomography to measure tissue perfusion in spontaneous canine tumors. | |
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MedLine Citation:
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PMID: 19697597 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dynamic computed tomography (CT) is widely used in humans to determine tumor perfusion via time-attenuation curves. Five types of time-attenuation curves have been identified and shown to have prognostic relevance in humans. The goal of our study was to assess the feasibility of this technology in spontaneous canine tumors and to determine time-attenuation curves and perfusion patterns in different tumor types. Thirty-one dogs with tumors accessible for biopsy were evaluated (15 carcinomas, 16 sarcomas). Dynamic CT was performed at the level of the largest tumor cross-section. Time-attenuation curves were calculated and ratios from the tumor to a contralateral artery were derived for wash-in, peak attenuation, time to peak attenuation, wash-out, and perfusion. Median perfusion was significantly higher and median time to peak ratio was significantly shorter in carcinomas and bone sarcomas compared with soft tissue sarcomas (P = 0.03 and 0.01). There was a trend of lower median upslope and wash-out ratio in soft tissue sarcomas in comparison with carcinomas (P = 0.06 and 0.09). Although peak ratio was lowest in soft tissue sarcomas, differences were not significant (P = 0.3). The most common type of time-attenuation curve for all tumors had a slow to moderately rapid wash-in with a low to moderate attenuation peak followed by a plateau phase. In conclusion, dynamic CT is feasible and time-activity curve-derived measurements differed between spontaneous canine tumors. More data has to be collected in a larger number of patients and correlated with response to treatment and outcome. |
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Authors:
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Dagmar Nitzl; Stefanie Ohlerth; Fabienne Mueller-Schwandt; Andrea Angst; Malgorzata Roos; Barbara Kaser-Hotz |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association Volume: 50 ISSN: 1058-8183 ISO Abbreviation: - Publication Date: 2009 Jul-Aug |
Date Detail:
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Created Date: 2009-08-24 Completed Date: 2009-10-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9209635 Medline TA: Vet Radiol Ultrasound Country: United States |
Other Details:
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Languages: eng Pagination: 347-52 Citation Subset: IM |
Affiliation:
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Diagnostic Imaging and Radio-Oncology, Vetsuisse-Faculty of the University of Zurich, Zurich, Switzerland. nitzl@aoicenter.ch |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bone Neoplasms / radiography, veterinary Carcinoma / radiography, veterinary* Dog Diseases / radiography* Dogs Female Male Sarcoma / radiography, veterinary* Soft Tissue Neoplasms / radiography, veterinary Tomography, X-Ray Computed / veterinary* |
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