| Dynamic characterization and hemodynamic effects of pulmonary waves in fetal lambs using cardiac extrasystoles and beat-by-beat wave intensity analysis. | |
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MedLine Citation:
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PMID: 19494171 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Steady-state wave intensity (WI) analysis indicates that characteristic midsystolic falls in fetal pulmonary trunk (PT) and artery (PA) blood flow are due to an extremely large backward-running compression wave (BCW(ms)) that 1) originates from the pulmonary microvasculature by a combination of cyclical pulmonary vasoconstriction and vascular reflection of the forward-running compression wave (FCW(is)) associated with impulsive right ventricular ejection, and 2) is transmitted into the PT. However, no information is available about the dynamic properties of PA BCW(ms) and its contribution to beat-to-beat regulation of pulmonary hemodynamics. Accordingly, beat-by-beat WI analysis was performed during brief increases in ventricular contractility accompanying an extrasystole (ES) in nine anesthetized late-gestation fetal sheep instrumented with PT and left PA micromanometer catheters to measure pressure (P) and transit-time flow probes to obtain blood velocity (U). WI was calculated as the product of P and U rates of change. At steady state, the magnitude of PA BCW(ms), and its associated P and U changes (DeltaP and DeltaU, respectively), were similar to those of FCW(is). The PA FCW(is) and BCW(ms), and their accompanying DeltaP and DeltaU, were all transiently potentiated after an ES. Beat-by-beat PA FCW(is)-BCW(ms) wave area, DeltaP and DeltaU relationships were highly linear (R(2) > or = 0.91) with slopes of 1.36-1.47 (P < 0.001), consistent with the presence of a vasoconstrictor component in PA BCW(ms). PA-PT BCW(ms) area and DeltaP and DeltaU relationships were also linear (R(2) > or = 0.77) with slopes of 0.23-0.64 (P < 0.001). These results indicate that the fetal PA BCW(ms) contributes to beat-to-beat regulation of not only PA but also PT hemodynamics. |
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Authors:
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Joseph J Smolich; Jonathan P Mynard; Daniel J Penny |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-06-03 |
Journal Detail:
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Title: American journal of physiology. Regulatory, integrative and comparative physiology Volume: 297 ISSN: 1522-1490 ISO Abbreviation: Am. J. Physiol. Regul. Integr. Comp. Physiol. Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-07-22 Completed Date: 2009-08-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901230 Medline TA: Am J Physiol Regul Integr Comp Physiol Country: United States |
Other Details:
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Languages: eng Pagination: R428-36 Citation Subset: IM |
Affiliation:
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Heart Research Group, Murdoch Children's Research Institute, Melbourne, Australia. joe.smolich@mcri.edu.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Flow Velocity / physiology Blood Gas Analysis Blood Pressure / physiology Cardiac Complexes, Premature / physiopathology* Female Fetus / physiology* Heart Rate / physiology* Hemodynamics / physiology* Pregnancy Pulmonary Artery / physiology Pulmonary Circulation / physiology* Sheep Ventricular Function, Right / physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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