Document Detail

Dynamic changes in type I collagen, MMP-1 and TIMP-1 after angioplasty.
MedLine Citation:
PMID:  11940362     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the dynamic changes of type I collagen, and the activity of metalloproteinases-1 (MMP-1) and tissue inhibitor of metalloproteinases-1 (TIMP-1) after angioplasty. METHODS: The restenotic model of iliac arteries of domestic microswine was established with hypercholesterol feed plus two angioplasties. Angioplastied vessels were harvested at the end of 1, 2, 3 and 6 months after the second angioplasty. Immunohistochemistry, transmission electronic microscopy and image quantitative analysis techniques were employed to study neointimal proliferation, the phenotype of vascular smooth muscle cells (VSMC) and the expression of type I collagen, MMP-1 and TIMP-1. RESULTS: The peak of vascular neointimal proliferation was at 3 months after angioplasty. The expression of type I collagen gradually increased from 1 to 6 months after angioplasty. For MMP-1, expression was lower in the early stage after angioplasty but increase to normal levels of control vessels at 6 months after angioplasty. Expression of TIMP-1 rapidly increased in the early phase after angioplasty, reached peak at 3 months and maintained the high level till 6 months after angioplasty. Meanwhile, the VSMC was predominantly the synthetic phenotype at the early stage and was transformed to the contractive phenotype at the late stage after angioplasty. The ratio of TIMP-1 and MMP-1 was positively related to the area of the neointima and the expression of type I collagen respectively (P < 0.01). CONCLUSION: Type I collagen increased gradually after angioplasty, which might be determined by the ratio of TIMP-1/MMP-1 and also related to the phenotype of VSMC.
Dingcheng Xiang; Jianxin He; Chuanhong Yang; Zhihua Gong; Huangwen Lai; Ruibin Fu; Shaodong Yi; Jian Qiu
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chinese medical journal     Volume:  115     ISSN:  0366-6999     ISO Abbreviation:  Chin. Med. J.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-04-09     Completed Date:  2002-05-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7513795     Medline TA:  Chin Med J (Engl)     Country:  China    
Other Details:
Languages:  eng     Pagination:  352-4     Citation Subset:  IM    
Department of Cardiology, General Hospital of Guangzhou Command, Guangzhou 510010, China.
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MeSH Terms
Arterial Occlusive Diseases / metabolism,  surgery
Collagen Type I / metabolism*
Iliac Artery / surgery
Matrix Metalloproteinase 1 / metabolism*
Muscle, Smooth, Vascular / cytology,  metabolism*
Swine, Miniature
Tissue Inhibitor of Metalloproteinase-1 / metabolism*
Reg. No./Substance:
0/Collagen Type I; 0/Tissue Inhibitor of Metalloproteinase-1; EC Metalloproteinase 1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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