| Dynamic changes in type I collagen, MMP-1 and TIMP-1 after angioplasty. | |
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MedLine Citation:
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PMID: 11940362 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the dynamic changes of type I collagen, and the activity of metalloproteinases-1 (MMP-1) and tissue inhibitor of metalloproteinases-1 (TIMP-1) after angioplasty. METHODS: The restenotic model of iliac arteries of domestic microswine was established with hypercholesterol feed plus two angioplasties. Angioplastied vessels were harvested at the end of 1, 2, 3 and 6 months after the second angioplasty. Immunohistochemistry, transmission electronic microscopy and image quantitative analysis techniques were employed to study neointimal proliferation, the phenotype of vascular smooth muscle cells (VSMC) and the expression of type I collagen, MMP-1 and TIMP-1. RESULTS: The peak of vascular neointimal proliferation was at 3 months after angioplasty. The expression of type I collagen gradually increased from 1 to 6 months after angioplasty. For MMP-1, expression was lower in the early stage after angioplasty but increase to normal levels of control vessels at 6 months after angioplasty. Expression of TIMP-1 rapidly increased in the early phase after angioplasty, reached peak at 3 months and maintained the high level till 6 months after angioplasty. Meanwhile, the VSMC was predominantly the synthetic phenotype at the early stage and was transformed to the contractive phenotype at the late stage after angioplasty. The ratio of TIMP-1 and MMP-1 was positively related to the area of the neointima and the expression of type I collagen respectively (P < 0.01). CONCLUSION: Type I collagen increased gradually after angioplasty, which might be determined by the ratio of TIMP-1/MMP-1 and also related to the phenotype of VSMC. |
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Authors:
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Dingcheng Xiang; Jianxin He; Chuanhong Yang; Zhihua Gong; Huangwen Lai; Ruibin Fu; Shaodong Yi; Jian Qiu |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Chinese medical journal Volume: 115 ISSN: 0366-6999 ISO Abbreviation: Chin. Med. J. Publication Date: 2002 Mar |
Date Detail:
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Created Date: 2002-04-09 Completed Date: 2002-05-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7513795 Medline TA: Chin Med J (Engl) Country: China |
Other Details:
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Languages: eng Pagination: 352-4 Citation Subset: IM |
Affiliation:
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Department of Cardiology, General Hospital of Guangzhou Command, Guangzhou 510010, China. DCXIANG@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angioplasty* Animals Arterial Occlusive Diseases / metabolism, surgery Collagen Type I / metabolism* Iliac Artery / surgery Matrix Metalloproteinase 1 / metabolism* Muscle, Smooth, Vascular / cytology, metabolism* Swine, Miniature Tissue Inhibitor of Metalloproteinase-1 / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Collagen Type I; 0/Tissue Inhibitor of Metalloproteinase-1; EC 3.4.24.7/Matrix Metalloproteinase 1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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