Document Detail


Dynamic changes in serum monocyte chemoattractant protein-1, and regulated upon activation, normal T cell expressed and secreted levels in patients with minor intracerebral hemorrhage.
MedLine Citation:
PMID:  23022895     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
OBJECTIVE: To investigate the time expression profile of serum monocyte chemoattractant protein (MCP)-1, and regulated upon activation, normal T cell expressed and secreted (RANTES) after minor intracerebral hemorrhage (ICH).
METHODS: This study was carried out in the Department of Neurology in the Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, China. Fifteen consecutive hospitalized patients with minor ICH were enrolled from July 2008 to December 2008. The patients` serum levels of MCP-1 and RANTES were measured by enzyme-linked immunosorbent assay (ELISA) on days 1-3, 7, 14, and 30 after the onset of ICH, and compared with that of 10 controls.
RESULTS: The serum MCP-1 levels increased immediately on days 1-3 (p=0.000) after onset, and then decreased slightly on day 7 (p=0.001), and day 14 (p=0.000); after day 14, the levels continued to increase and reached their highest levels on day 30 (p=0.000). No statistical differences in MCP-1 levels were found between any time points. The RANTES levels at any time point did not differ significantly from the controls. The levels of MCP-1 and RANTES were not correlated with the serum C-reactive protein (CRP) levels, brain hematoma volumes, acute neurologic impairment, or 3-month outcome.
CONCLUSION: The persistent elevation of serum MCP-1 levels after minor ICH may contribute to the acute damage and the repair following an ICH.
Authors:
Zhendong Li; Shijian Luo; Yuhua Fan; Huabin Sun
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurosciences (Riyadh, Saudi Arabia)     Volume:  17     ISSN:  1319-6138     ISO Abbreviation:  Neurosciences (Riyadh)     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101252453     Medline TA:  Neurosciences (Riyadh)     Country:  Saudi Arabia    
Other Details:
Languages:  eng     Pagination:  314-20     Citation Subset:  IM    
Affiliation:
Department of Neurology, the Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, Guangdong Province, China. Tel. +86 (0756) 2528725. Fax. +86 (0756) 2528333. E-mail: lizdsysu@163.com.
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