| Dynamic changes in serum monocyte chemoattractant protein-1, and regulated upon activation, normal T cell expressed and secreted levels in patients with minor intracerebral hemorrhage. | |
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MedLine Citation:
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PMID: 23022895 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the time expression profile of serum monocyte chemoattractant protein (MCP)-1, and regulated upon activation, normal T cell expressed and secreted (RANTES) after minor intracerebral hemorrhage (ICH). METHODS: This study was carried out in the Department of Neurology in the Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, China. Fifteen consecutive hospitalized patients with minor ICH were enrolled from July 2008 to December 2008. The patients` serum levels of MCP-1 and RANTES were measured by enzyme-linked immunosorbent assay (ELISA) on days 1-3, 7, 14, and 30 after the onset of ICH, and compared with that of 10 controls. RESULTS: The serum MCP-1 levels increased immediately on days 1-3 (p=0.000) after onset, and then decreased slightly on day 7 (p=0.001), and day 14 (p=0.000); after day 14, the levels continued to increase and reached their highest levels on day 30 (p=0.000). No statistical differences in MCP-1 levels were found between any time points. The RANTES levels at any time point did not differ significantly from the controls. The levels of MCP-1 and RANTES were not correlated with the serum C-reactive protein (CRP) levels, brain hematoma volumes, acute neurologic impairment, or 3-month outcome. CONCLUSION: The persistent elevation of serum MCP-1 levels after minor ICH may contribute to the acute damage and the repair following an ICH. |
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Authors:
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Zhendong Li; Shijian Luo; Yuhua Fan; Huabin Sun |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neurosciences (Riyadh, Saudi Arabia) Volume: 17 ISSN: 1319-6138 ISO Abbreviation: Neurosciences (Riyadh) Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101252453 Medline TA: Neurosciences (Riyadh) Country: Saudi Arabia |
Other Details:
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Languages: eng Pagination: 314-20 Citation Subset: IM |
Affiliation:
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Department of Neurology, the Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, Guangdong Province, China. Tel. +86 (0756) 2528725. Fax. +86 (0756) 2528333. E-mail: lizdsysu@163.com. |
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