Document Detail

Dynamic changes in insulin-like growth factor I immunoreactivity correlate to repair events in rat ear after freeze-thaw injury.
MedLine Citation:
PMID:  3653346     Owner:  NLM     Status:  MEDLINE    
The distribution of the trophic peptide insulin-like growth factor I (IGF-I) in the rat ear was mapped after freeze-thaw injury. Immunocytochemical methods and antisera specific to human IGF-I were used. In the ear of normal adult rats scattered basal epidermal cells and a few cells in the underlying connective tissue and elastic cartilage expressed IGF-I immunoreactivity. Within 1 day after injury and reaching maximum in 3 days, all epidermal cells became stained as did invading macrophages and some of the other inflammatory cells. Concomitantly, there were hypertrophic changes. The staining leveled off after 1-2 weeks. Perichondrial cells became IGF-I immunoreactive in increasing frequency during the first week, reached maximal intensity and frequency in 2 weeks, and remained stained for at least 4 weeks. New cartilage was formed concomitantly on both sides of the old one. It is proposed that IGF-I is a substance of general importance for cell maintenance and tissue repair.
E Jennische; A Skottner; H A Hansson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Experimental and molecular pathology     Volume:  47     ISSN:  0014-4800     ISO Abbreviation:  Exp. Mol. Pathol.     Publication Date:  1987 Oct 
Date Detail:
Created Date:  1987-11-20     Completed Date:  1987-11-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370711     Medline TA:  Exp Mol Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  193-201     Citation Subset:  IM    
Department of Histology, University of Gothenburg, Sweden.
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MeSH Terms
Ear Cartilage / metabolism,  pathology
Ear, External / injuries,  metabolism,  pathology
Edema / metabolism
Epidermis / metabolism,  pathology
Epithelium / metabolism,  pathology
Inflammation / metabolism
Insulin-Like Growth Factor I / metabolism*
Rats, Inbred Strains
Somatomedins / metabolism*
Wound Healing*
Reg. No./Substance:
0/Somatomedins; 67763-96-6/Insulin-Like Growth Factor I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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