Document Detail


Dynamic changes in cardiac fatty acid metabolism in the stunned human myocardium.
MedLine Citation:
PMID:  11577759     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The chronological changes or mechanisms in cardiac fatty acid metabolism under clinical conditions of hypoxia and ischemia have not been fully elucidated. 123-15-(p-iodophenyl)-3-R,S-methylpentadecanoic acid (BMIPP) can be used with single photon emission computed tomography (SPECT) to evaluate myocardial fatty acid metabolism. We investigated chronological changes in energy metabolism in the stunned human myocardium by means of 123I-BMIPP myocardial SPECT. METHODS AND RESULTS: We conducted 123I-BMIPP myocardial SPECT in 10 patients with stunned myocardium during the acute, subacute and chronic phases after onset. The left ventricle was divided into 9 regions on SPECT, and the degree of abnormalities in each region was scored in four grades from normal (0) to defect (4). We also examined wash-out rates on BMIPP images. The scores on early BMIPP images in the acute, subacute and chronic phases were 5.6 +/- 1.8, 13.4 +/- 3.5 and 2.5 +/- 1.1, respectively, and the score was highest in the subacute phase (p < 0.001). Similarly, scores on the late images were 2.3 +/- 1.7, 18.3 +/- 4.5 and 4.7 +/- 2.6, respectively, and highest in the subacute phase (p < 0.001). The wash-out rates (normal: 18.2 +/- 2.1%) in the acute, subacute and chronic phases were 12.1 +/- 4.8%, 44.9 +/- 10.0% and 23.1 +/- 4.6%, respectively, with the value being lowest during the acute phase (p < 0.05), and highest during the subacute phase (p < 0.001). CONCLUSION: These results suggested that fatty acid metabolism in the stunned human myocardium changes dynamically over time.
Authors:
K Ito; H Sugihara; T Kawasaki; S Katoh; A Azuma; M Nakagawa
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Annals of nuclear medicine     Volume:  15     ISSN:  0914-7187     ISO Abbreviation:  Ann Nucl Med     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-10-01     Completed Date:  2002-03-11     Revised Date:  2006-05-06    
Medline Journal Info:
Nlm Unique ID:  8913398     Medline TA:  Ann Nucl Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  343-50     Citation Subset:  IM    
Affiliation:
Division of Cardiology, Murakami Memorial Hospital, Asahi University, Japan. kazuki@poppy.ocn.ne.jp
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MeSH Terms
Descriptor/Qualifier:
Aged
Echocardiography
Energy Metabolism
Fatty Acids / diagnostic use,  metabolism*
Female
Heart / radionuclide imaging
Humans
Iodine Radioisotopes / diagnostic use
Iodobenzenes / diagnostic use
Male
Middle Aged
Myocardial Stunning / metabolism*,  radionuclide imaging,  ultrasonography
Myocardium / metabolism*
Organophosphorus Compounds / diagnostic use
Organotechnetium Compounds / diagnostic use
Radiopharmaceuticals / diagnostic use
Time Factors
Tomography, Emission-Computed, Single-Photon
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Iodine Radioisotopes; 0/Iodobenzenes; 0/Organophosphorus Compounds; 0/Organotechnetium Compounds; 0/Radiopharmaceuticals; 0/technetium Tc 99m 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane; 116754-87-1/iodofiltic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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