Document Detail

Dynamic cerebral autoregulation during sevoflurane anesthesia: a comparison with isoflurane.
MedLine Citation:
PMID:  9972753     Owner:  NLM     Status:  MEDLINE    
We investigated dynamic cerebral pressure autoregulation awake and during 1.5 minimum alveolar anesthetic concentration (MAC) sevoflurane or isoflurane anesthesia in 16 patients undergoing nonintracranial neurosurgical procedures. All patients received a standardized anesthetic, and their lungs were ventilated with 1.5 MAC volatile anesthetic in 100% oxygen to normocapnia. Routine monitors included electrocardiogram, pulse oximetry, end-tidal capnography, and continuous noninvasive blood pressure. In addition, middle cerebral artery blood velocity (Vmca) was measured continuously using transcranial Doppler ultrasonography. Dynamic cerebral autoregulation was tested by inducing a rapid transient decrease in mean arterial pressure by deflation of large thigh cuffs, which were placed around both thighs and inflated to 100 mm Hg above systolic pressure. The Vmca response to the decrease in blood pressure was fitted to a series of curves to determine the rate of dynamic cerebral autoregulation (dRoR). Awake dRoR values were similar in the isoflurane and sevoflurane groups, 32 +/- 2%/s and 29 +/- 2%/s, respectively. dRoR decreased to 5 +/- 1%/s during isoflurane anesthesia but to only 24 +/- 2%/s during sevoflurane anesthesia. We conclude that dynamic cerebral autoregulation is better preserved during sevoflurane than isoflurane anesthesia in humans. Implications: We investigated the effect of sevoflurane and isoflurane on dynamic cerebral pressure autoregulation using transcranial Doppler ultrasonography. At 1.5 minimum alveolar anesthetic concentration, dynamic autoregulation was better preserved during sevoflurane than isoflurane anesthesia.
A C Summors; A K Gupta; B F Matta
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  88     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-02-23     Completed Date:  1999-02-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  341-5     Citation Subset:  AIM; IM    
Department of Anesthesia, Addenbrooke's Hospital, Cambridge, United Kingdom.
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MeSH Terms
Anesthetics, Inhalation / administration & dosage*
Blood Flow Velocity / drug effects
Blood Pressure / drug effects
Brain / drug effects*
Carbon Dioxide / analysis
Cerebral Arteries / drug effects,  ultrasonography
Cerebrovascular Circulation / drug effects
Heart Rate / drug effects
Homeostasis / drug effects*
Intracranial Pressure / drug effects
Isoflurane / administration & dosage*
Methyl Ethers / administration & dosage*
Middle Aged
Respiration, Artificial
Tidal Volume
Ultrasonography, Doppler, Transcranial
Wakefulness / physiology
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Methyl Ethers; 124-38-9/Carbon Dioxide; 26675-46-7/Isoflurane; 28523-86-6/sevoflurane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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