Document Detail


Dynamic brain mapping of behavior change: tracking response initiation and inhibition to changes in reinforcement rate.
MedLine Citation:
PMID:  22743002     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Adaptive behavior change is supported by executive control processes distributed throughout a prefrontal-striatal-parietal network. Yet, the temporal dynamics of regions in the network have not been characterized. Using functional magnetic resonance imaging (fMRI), we tracked changes brain activation while subjects initiated and inhibited responding in accordance with changes in reinforcement rate. During imaging, subjects completed a free-operant task that involved repeated transitions between fixed-ratio reinforcement and extinction (RF:EXT), where reinforcement rate decreased and responding was inhibited, and between extinction and fixed-ratio reinforcement (EXT:RF), where reinforcement rate increased and responding was initiated. Our whole-brain temporal assessment revealed that transitions which required initiating and inhibiting responding prompted positive phasic responses in a prefrontal-parietal network, the insula and thalamus. However, response initiation prompted by an increase in reinforcement rate during the EXT:RF transition elicited positive phasic responses in reward-sensitive striatal regions. Furthermore, response inhibition prompted by a decrease in reinforcement rate during the RF:EXT transition elicited negative phasic responses in ventral frontal regions sensitive to value and contingency. Our findings highlight the temporal dynamics of a brain network that supports behavioral changes (initiation and inhibition) resulting from changes in local reinforcement rates.
Authors:
Michael W Schlund; Sandy Magee; Caleb D Hudgins
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-25
Journal Detail:
Title:  Behavioural brain research     Volume:  -     ISSN:  1872-7549     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8004872     Medline TA:  Behav Brain Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier B.V.
Affiliation:
Department of Behavior Analysis, University of North Texas, Denton TX, USA; Department of Behavioral Psychology, Kennedy Krieger Institute, Baltimore MD, USA; Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore MD, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The Psychometric Hepatic Encephalopathy Score for the detection of minimal hepatic encephalopathy in...
Next Document:  Sleep-related cognitive function and the K-complex in schizophrenia.