Document Detail

Dynamic behaviour of coronary stenosis in response to increasing heart rate in the dog.
MedLine Citation:
PMID:  3256415     Owner:  NLM     Status:  MEDLINE    
In order to assess the responses of coronary stenosis to an elevation of myocardial metabolic demand, the effects of pacing induced tachycardia on systemic and coronary haemodynamics were examined during four grades of compliant coronary stenosis which preserved stenosis vasomotility in eight open chest dogs. Grades of the coronary stenosis were defined as trifling, mild, moderate, and severe by pressure gradients of 12(0.5), 19(1.0), 28(1.4) and 37(1.6) mm Hg (mean [SEM]), respectively. Stepwise increases in heart rate (+30, +60 and +90 beats.min-1) decreased the resistance caused by trifling and mild coronary stenosis by 47(11.9) and 26(8.8)%, respectively, with an increase in coronary blood flow and a decrease in pressure gradient across the stenosis. By contrast, the resistance caused by moderate and severe stenosis increased by 96(24.2) and 148(63.2)%, respectively, with a decrease in coronary blood flow and an increase in pressure gradient. During lower grades of coronary stenosis, flow-dependent dilatation of large epicardial coronary arteries reduced the stenosis severity, whereas during higher grades of stenosis, passive narrowing of the stenosed arterial segment due to arteriolar vasodilatation outstripped the flow-dependent stenosis dilator effects and resulted in an intensification of the stenosis.
M Yokoyama; S Sakamoto; M Kashiki; H Fukuzaki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cardiovascular research     Volume:  22     ISSN:  0008-6363     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  1988 Oct 
Date Detail:
Created Date:  1989-10-16     Completed Date:  1989-10-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  708-13     Citation Subset:  IM    
First Department of Medicine, Kobe University School of Medicine, Japan.
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MeSH Terms
Coronary Circulation
Coronary Disease / pathology,  physiopathology*
Coronary Vessels / pathology,  physiopathology
Electric Stimulation
Heart Rate*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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