| Dynamic amino acid increases in the basolateral amygdala during acquisition and expression of conditioned fear. | |
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MedLine Citation:
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PMID: 16820029 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Glutamate and gamma-aminobutyric acid (GABA) release in the amygdala are thought to be crucial for the acquisition and expression of fear memories, but the time course of amino acid changes during conditioning is unknown. We used rapid-sampling microdialysis with 14 s temporal resolution to address this issue. During auditory fear conditioning, large, rapid and transient increases in glutamate and GABA were detected, but only during the first noise-shock pairing. In contrast, rats receiving unsignaled shocks during contextual fear conditioning showed no changes in GABA and less glutamate release for the initial shock, but increased glutamate release during later shocks. Expression of conditioned fear to either a white noise or the context previously paired with shock produced similar rapid and transient increases in many amino acids in the amygdala. These experiments demonstrate glutamate and GABA levels in the amygdala are differentially modulated during auditory and contextual fear learning, and are transiently increased during the expression of fear memories. |
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Authors:
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B Jill Venton; Terry E Robinson; Robert T Kennedy; Stephen Maren |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: The European journal of neuroscience Volume: 23 ISSN: 0953-816X ISO Abbreviation: Eur. J. Neurosci. Publication Date: 2006 Jun |
Date Detail:
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Created Date: 2006-07-05 Completed Date: 2007-04-03 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 8918110 Medline TA: Eur J Neurosci Country: France |
Other Details:
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Languages: eng Pagination: 3391-8 Citation Subset: IM |
Affiliation:
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Department of Chemistry, University of Michigan, 930 N. University, Ann Arbor, MI 48109-1055, USA. bjv2n@virginia.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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metabolism* Amygdala / anatomy & histology, metabolism* Animals Conditioning (Psychology)* Electric Stimulation Fear / physiology* Glutamic Acid / metabolism Learning / physiology* Male Memory / physiology Microdialysis Rats Rats, Sprague-Dawley gamma-Aminobutyric Acid / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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R01 MH073655/MH/NIMH NIH HHS; R01 NS38476/NS/NINDS NIH HHS; R37 DA004294/DA/NIDA NIH HHS; T32 DA007268/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 56-12-2/gamma-Aminobutyric Acid; 56-86-0/Glutamic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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