Document Detail


Dynamic amino acid increases in the basolateral amygdala during acquisition and expression of conditioned fear.
MedLine Citation:
PMID:  16820029     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Glutamate and gamma-aminobutyric acid (GABA) release in the amygdala are thought to be crucial for the acquisition and expression of fear memories, but the time course of amino acid changes during conditioning is unknown. We used rapid-sampling microdialysis with 14 s temporal resolution to address this issue. During auditory fear conditioning, large, rapid and transient increases in glutamate and GABA were detected, but only during the first noise-shock pairing. In contrast, rats receiving unsignaled shocks during contextual fear conditioning showed no changes in GABA and less glutamate release for the initial shock, but increased glutamate release during later shocks. Expression of conditioned fear to either a white noise or the context previously paired with shock produced similar rapid and transient increases in many amino acids in the amygdala. These experiments demonstrate glutamate and GABA levels in the amygdala are differentially modulated during auditory and contextual fear learning, and are transiently increased during the expression of fear memories.
Authors:
B Jill Venton; Terry E Robinson; Robert T Kennedy; Stephen Maren
Related Documents :
12422519 - Regulation of the production of polygalacturonase by aspergillus niger.
22833869 - Malonyl-coa: the regulator of fatty acid synthesis and oxidation.
9453229 - Lactate formation from [u-13c]aspartate in cultured astrocytes: compartmentation of pyr...
20921909 - A trial to assess the efficacy of glutamic acid in prevention of vincristine-induced ne...
10646529 - Acidic amino acid clearance from csf in the neonatal versus adult rat using ventriculo-...
24672789 - Animal model of acid-reflux esophagitis: pathogenic roles of acid/pepsin, prostaglandin...
2172099 - Use of salicylate as a probe for .oh formation in isolated ischemic rat hearts.
7025609 - Pantothenic acid nutritional status in the elderly--institutionalized and noninstitutio...
8360949 - Changes of amino acid and monoamine levels after neonatal 6-hydroxydopamine denervation...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The European journal of neuroscience     Volume:  23     ISSN:  0953-816X     ISO Abbreviation:  Eur. J. Neurosci.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-07-05     Completed Date:  2007-04-03     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  8918110     Medline TA:  Eur J Neurosci     Country:  France    
Other Details:
Languages:  eng     Pagination:  3391-8     Citation Subset:  IM    
Affiliation:
Department of Chemistry, University of Michigan, 930 N. University, Ann Arbor, MI 48109-1055, USA. bjv2n@virginia.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Amino Acids / metabolism*
Amygdala / anatomy & histology,  metabolism*
Animals
Conditioning (Psychology)*
Electric Stimulation
Fear / physiology*
Glutamic Acid / metabolism
Learning / physiology*
Male
Memory / physiology
Microdialysis
Rats
Rats, Sprague-Dawley
gamma-Aminobutyric Acid / metabolism
Grant Support
ID/Acronym/Agency:
R01 MH073655/MH/NIMH NIH HHS; R01 NS38476/NS/NINDS NIH HHS; R37 DA004294/DA/NIDA NIH HHS; T32 DA007268/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Amino Acids; 56-12-2/gamma-Aminobutyric Acid; 56-86-0/Glutamic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Pheromonal recognition memory induced by TRPC2-independent vomeronasal sensing.
Next Document:  Motor strategies and excitability changes of human hand motor area are dependent on different volunt...