| Dynamic Synchrotron Imaging of Diabetic Rat Coronary Microcirculation In Vivo. | |
| | |
MedLine Citation:
|
PMID: 22075246 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVE: In diabetes, long-term micro- and macrovascular damage often underlies the functional decline in the cardiovascular system. However, it remains unclear whether early-stage diabetes is associated with in vivo functional impairment in the coronary microvasculature. Synchrotron imaging allows us to detect and quantify regional differences in resistance microvessel caliber in vivo, even under conditions of high heart rate. METHODS AND RESULTS: Synchrotron cine-angiograms of the coronary vasculature were recorded using anesthetized Sprague-Dawley rats 3 weeks after treatment with vehicle or streptozotocin (diabetic). In the early diabetic state, in the presence of nitric oxide and prostacyclin , vessel diameters were smaller (P<0.01) and endothelium-dependent vessel recruitment was already depressed (P<0.05). Endothelium-dependent and -independent vasodilatory responses in individual coronary vessels were not different in vivo. Inhibition of NO and PGI(2) production in diabetes uncovered early localized impairment in dilation. Diabetic animals displayed focal stenoses and segmental constrictions during nitric oxide synthase/cyclooxygenase blockade, which persisted during acetylcholine infusion (P<0.05), and a strong trend toward loss of visible microvessels. CONCLUSIONS: Synchrotron imaging provides a novel method to investigate coronary microvascular function in vivo at all levels of the arterial tree. Furthermore, we have shown that early-stage diabetes is associated with localized coronary microvascular endothelial dysfunction. |
| | |
Authors:
|
Mathew J Jenkins; Amanda J Edgley; Takashi Sonobe; Keiji Umetani; Daryl O Schwenke; Yutaka Fujii; Russell D Brown; Darren J Kelly; Mikiyasu Shirai; James T Pearson |
Related Documents
:
|
1107346 - Carbohydrate metabolism in pregnancy: xiii. relationships between plasma insulin and pr... 21722676 - Diabetes impairs learning performance through affecting membrane excitability of hippoc... 1959706 - Hyperinsulinaemia in obesity is not accompanied by an increase in serum proinsulin/insu... 11168336 - Is the defect in pro-hormone processing in type 2 diabetes mellitus restricted to the b... 20698126 - Visual evoked potential can be used to detect a prediabetic form of diabetic retinopath... 3662696 - Differential contractile responsiveness of femoral arteries from healthy and diabetic d... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-11-10 |
Journal Detail:
|
Title: Arteriosclerosis, thrombosis, and vascular biology Volume: - ISSN: 1524-4636 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-11-14 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9505803 Medline TA: Arterioscler Thromb Vasc Biol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Medicine, St. Vincent's Hospital, University of Melbourne, Melbourne, Australia; Department of Physiology, Monash University, Melbourne, Australia; National Cerebral and Cardiovascular Center Research Institute, Suita, Japan; Japan Synchrotron Radiation Research Institute, Harima, Japan; Department of Physiology, Otago University, Dunedin, New Zealand; Monash Biomedical Imaging Facility, Melbourne, Australia; Australian Synchrotron, Melbourne, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Urokinase Receptor Associates With Myocardin to Control Vascular Smooth Muscle Cells Phenotype in Va...
Next Document: Objectively Assessed Physical Activity, Sedentary Time, and Coronary Artery Calcification in Healthy...