| Dynamic MRI using iron oxide nanoparticles to assess early vascular effects of antiangiogenic versus corticosteroid treatment in a glioma model. | |
| | |
MedLine Citation:
|
PMID: 19142191 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The vascular effects of antiangiogenic treatment may pose problems for evaluating brain tumor response based on contrast-enhanced magnetic resonance imaging (MRI). We used serial dynamic contrast-enhanced MRI at 12 T to assess vascular responses to antiangiogenic versus steroid therapy. Athymic rats with intracerebral U87MG human glioma (n=17) underwent susceptibility-weighted perfusion MRI with ferumoxytol, a solely intravascular ultrasmall superparamagnetic iron oxide (USPIO) nanoparticle, followed by T1-weighted dynamic gadodiamide-enhanced MRI to measure vascular permeability. Rats were imaged before and after 24, 48, and 72 h of treatment with the antiangiogenic agent bevacizumab or the corticosteroid dexamethasone. Contrast agent extravasation was seen rapidly after gadodiamide, but not with ferumoxytol administration. Bevacizumab significantly decreased the blood volume and decreased permeability in tumors as determined by increased time-to-peak enhancement. A single dose of 45 mg/kg bevacizumab resulted in changes analogous to dexamethasone given in an extremely high dose (12 mg/kg per day), and was significantly more effective than dexamethasone at 2 mg/kg per day. We conclude that dynamic perfusion MRI measurements with ferumoxytol USPIO to assess cerebral blood volume, along with dynamic gadodiamide-enhanced MR to assess vascular permeability, hold promise in more accurately detecting therapeutic responses to antiangiogenic therapy. |
| | |
Authors:
|
Csanad G Varallyay; Leslie L Muldoon; Seymur Gahramanov; Yingjen J Wu; James A Goodman; Xin Li; Martin M Pike; Edward A Neuwelt |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2009-01-14 |
Journal Detail:
|
Title: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Volume: 29 ISSN: 1559-7016 ISO Abbreviation: J. Cereb. Blood Flow Metab. Publication Date: 2009 Apr |
Date Detail:
|
Created Date: 2009-04-01 Completed Date: 2009-05-06 Revised Date: 2010-10-04 |
Medline Journal Info:
|
Nlm Unique ID: 8112566 Medline TA: J Cereb Blood Flow Metab Country: United States |
Other Details:
|
Languages: eng Pagination: 853-60 Citation Subset: IM |
Affiliation:
|
Department of Neuroradiology, Universitätsklinikum Würzburg, Würzburg, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adrenal Cortex Hormones
/
therapeutic use* Angiogenesis Inhibitors / therapeutic use* Animals Antibodies, Monoclonal / therapeutic use Capillary Permeability Cerebrovascular Circulation / drug effects Dexamethasone / therapeutic use Disease Models, Animal Drug Monitoring / methods Ferric Compounds / diagnostic use* Gadolinium DTPA / diagnostic use Glioma / diagnosis, drug therapy* Humans Kinetics Magnetic Resonance Imaging / methods* Nanoparticles / diagnostic use* Rats |
| Grant Support | |
ID/Acronym/Agency:
|
NS33618/NS/NINDS NIH HHS; NS44687/NS/NINDS NIH HHS; NS53468/NS/NINDS NIH HHS; R01 CA137488-14A1/CA/NCI NIH HHS; R01 NS053468-03/NS/NINDS NIH HHS; R37 NS044687-26/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Adrenal Cortex Hormones; 0/Angiogenesis Inhibitors; 0/Antibodies, Monoclonal; 0/Ferric Compounds; 0/bevacizumab; 122795-43-1/gadodiamide; 1309-37-1/ferric oxide; 50-02-2/Dexamethasone; 80529-93-7/Gadolinium DTPA |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cooling combined with immediate or delayed xenon inhalation provides equivalent long-term neuroprote...
Next Document: Transient focal ischemia induces extensive temporal changes in rat cerebral microRNAome.