| Dynamic MRI of the small bowel: usefulness of quantitative contrast-enhancement parameters and time-signal intensity curves for differentiating between active and inactive Crohn's disease. | |
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MedLine Citation:
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PMID: 20509025 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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PURPOSE: To assess Crohn's disease (CD) activity through analysis of time-signal intensity curves and quantitative contrast-enhancement parameters on dynamic contrast-enhanced MRI. MATERIALS AND METHODS: 70 patients (male:female = 44:26, age 15-45 years, mean 27.8 years) with biopsy-proven clinically active or inactive CD, underwent dynamic contrast-enhanced MRI after oral administration of iso-osmotic solution. Time-signal intensity curves were classified according to their shape as type I (early upslope with late plateau) and type II (slow contrast material wash-in with late wash-out). Curve parameters such as maximum enhancement (ME), the ratio between late and ME (LE/ME), and UpSlope (US) were compared between patients with active and inactive CD (two-tailed Mann-Whitney test). Sensitivity, specificity, and cut-off for each parameter were calculated by means of receiver operating characteristic curve (ROC) analysis. RESULTS: 53/53 patients with active CD and 17/17 with inactive CD showed type I and type II curves, respectively. ME, LE/ME, and US were significantly higher in active than in inactive CD. ME, LE/ME, and US had sensitivity and specificity of 100%:100%:100% and 100%:83%:100% with cut-offs of 135.5:0.8909:2, respectively. CONCLUSIONS: Qualitative and quantitative analysis of time-signal intensity curves obtained with dynamic contrast-enhanced MRI allow reliable noninvasive differentiation between active and inactive CD. |
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Authors:
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Sabina Giusti; Lorenzo Faggioni; Emanuele Neri; Elena Fruzzetti; Letizia Nardini; Santino Marchi; Carlo Bartolozzi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Abdominal imaging Volume: 35 ISSN: 1432-0509 ISO Abbreviation: Abdom Imaging Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9303672 Medline TA: Abdom Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 646-53 Citation Subset: IM |
Affiliation:
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Department of Radiology, University of Pisa, Italy. s.giusti@med.unipi.it |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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