| Dynamic Interaction Between the Heart and its Sympathetic Innervation Following T5 Spinal Cord Transection. | |
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MedLine Citation:
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PMID: 22723636 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Mid-thoracic spinal cord injury (SCI) is associated with enhanced sympathetic support of heart rate as well as myocardial damage related to calcium overload. The myocardial damage may elicit an enhanced sympathetic support of contractility to maintain ventricular function. In contrast, the level of inotropic drive may be reduced to match the lower afterload that results from the injury induced reduction in arterial pressure. Accordingly, the inotropic response to mid-thoracic SCI may be increased or decreased; but has not been investigated and therefore remains unknown. Furthermore, the altered ventricular function may be associated with anatomical changes in cardiac sympathetic innervation. To determine the inotropic drive following mid-thoracic SCI, a telemetry device was used for repeated measurements of left ventricular (LV) function, with and without beta-adrenergic receptor blockade, in rats before and after mid-thoracic SCI or sham SCI. In addition, nerve growth factor (NGF) content (ELISA) and dendritic arborization (cholera toxin B immunohistochemistry and Sholl Analysis) of cardiac projecting sympathetic post-ganglionic neurons in the stellate ganglia were determined. Mid-thoracic SCI was associated with an enhanced sympathetic support of heart rate, dP/dt(+), and dP/dt(-). Importantly, cardiac function was lower following blockade of the sympathetic nervous system in rats with mid-thoracic SCI compared with sham operated rats. Finally, these functional neuroplastic changes were associated with an increased NGF content and structural neuroplasticity within the stellate ganglia. Results document impaired LV function with co-directional changes in chronotropic and inotropic responses following mid-thoracic SCI. These functional changes were associated with a dynamic interaction between the heart and its sympathetic innervation. |
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Authors:
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Heidi L Lujan; Hussein Janbaih; Stephen E Dicarlo |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-6-21 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: - ISSN: 1522-1601 ISO Abbreviation: - Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-6-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Wayne State University School of Medicine. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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