Document Detail

Dynamic Hypoxia in Scar Tissue During Human Hypertrophic Scar Progression.
MedLine Citation:
PMID:  24684437     Owner:  NLM     Status:  Publisher    
BACKGROUND: The skin color of human hypertrophic scar changes dynamically during scar progression.
OBJECTIVE: To investigate whether hypoxia is dynamic during scar progression.
METHODS: Thirty-five patients with early, proliferative, regressive, and mature scars were involved in this study. Tissue oxygen tension was measured before scar surgery. After surgery, the scar stage was further defined using hematoxylin and eosin staining, and microvessel density and hypoxia inducible factor-1 (HIF-1) expression were detected using immunohistochemistry to determine a correlation with oxygen level.
RESULTS: Mild hypoxia is present in early scars, moderate hypoxia in proliferative scars, and severe hypoxia in regressive scars. Oxygen levels then return to normal in mature scars, which was consistent with the dynamic change in microvessel density. Meanwhile, HIF-1 expression also changed dynamically along with alteration in oxygen levels.
CONCLUSION: Hypoxia is dynamic in scar tissue and is possibly correlated with scar formation and regression.
Jiexing Zheng; Fei Song; Shu-Liang Lu; Xi-Qiao Wang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-3-31
Journal Detail:
Title:  Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]     Volume:  -     ISSN:  1524-4725     ISO Abbreviation:  Dermatol Surg     Publication Date:  2014 Mar 
Date Detail:
Created Date:  2014-4-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9504371     Medline TA:  Dermatol Surg     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2014 by the American Society for Dermatologic Surgery, Inc. Published by Wiley Periodicals, Inc.
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