| Dynamic Contrast-Enhanced Magnetic Resonance Imaging-Derived kep as a Potential Biomarker of Matrix Metalloproteinase 9 Expression in Patients With Glioblastoma Multiforme: A Pilot Study. | |
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MedLine Citation:
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PMID: 22261782 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVE: To look for the association of tissue matrix metalloproteinase 9 (MMP-9) expression with dynamic contrast-enhanced magnetic resonance imaging and to see whether these can prognosticate patients with glioblastoma multiforme (GBM). METHODS: Forty-seven patients with GBM underwent dynamic contrast-enhanced magnetic resonance imaging to look for association of its indices with tissue MMP-9 expression using Pearson correlation. Kaplan-Meier survival analysis was performed to study the survival pattern for low-, medium-, and high-tissue MMP-9 expression and kep values. RESULTS: Among perfusion indices, kep, k, and ve significantly correlated with MMP-9 expression. Matrix metalloproteinase 9 expression was found to be best estimated by kep using a quadratic model. The 1-year survival in low-, medium-, and high-tissue MMP-9 and kep groups were 59%, 45%, and 7%, and 59%, 33%, and 15%, respectively. CONCLUSION: The association of kep and MMP-9 expression with survival suggests that kep may be used as imaging biomarker of GBM progression and its prognostication. |
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Authors:
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Rishi Awasthi; Chandra M Pandey; Prativa Sahoo; Sanjay Behari; Vijendra Kumar; Shaleen Kumar; Shagun Misra; Nuzhat Husain; Priyanka Soni; Ram K S Rathore; Rakesh Kumar Gupta |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of computer assisted tomography Volume: 36 ISSN: 1532-3145 ISO Abbreviation: J Comput Assist Tomogr Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-01-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7703942 Medline TA: J Comput Assist Tomogr Country: United States |
Other Details:
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Languages: eng Pagination: 125-30 Citation Subset: IM |
Affiliation:
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From the *Departments of Radiodiagnosis, and †Biostatistics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow; ‡Department of Mathematics and Statistics, Indian Institute of Technology, Kanpur; §Departments of Neurosurgery, and ∥Radiotherapy, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow; and ¶Department of Pathology, Chhatrapati Sahuji Maharj Medical University, Lucknow, India. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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