Document Detail


Short communication: dynamic constraints on the second phase compartment of HIV-infected cells.
MedLine Citation:
PMID:  21105850     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The cells responsible for the second phase decay of HIV-1 viremia following the initiation of antiretroviral therapy have yet to be identified. A dynamic model that considers where drugs act in the virus life cycle places constraints on candidate cell types. In this regard, the rapid drop in viremia in patients starting regimens containing the integrase inhibitor raltegravir is of particular interest. We show here that the time delay between reverse transcription and integration is short in differentiated macrophages, making these cells poor candidates for the second phase compartment under the assumptions of standard models of viral dynamics.
Authors:
Adam M Spivak; S Alireza Rabi; Moira A McMahon; Liang Shan; Ahmad R Sedaghat; Claus O Wilke; Robert F Siliciano
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-01-15
Journal Detail:
Title:  AIDS research and human retroviruses     Volume:  27     ISSN:  1931-8405     ISO Abbreviation:  AIDS Res. Hum. Retroviruses     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-28     Completed Date:  2011-10-12     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  8709376     Medline TA:  AIDS Res Hum Retroviruses     Country:  United States    
Other Details:
Languages:  eng     Pagination:  759-61     Citation Subset:  IM; X    
Affiliation:
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21218, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Anti-HIV Agents / pharmacology*
HIV Infections / drug therapy,  virology*
HIV-1 / drug effects*,  pathogenicity*
Humans
Macrophages / virology*
Virus Latency / drug effects*
Grant Support
ID/Acronym/Agency:
AI081600/AI/NIAID NIH HHS; AI51178/AI/NIAID NIH HHS; T32 AI007291/AI/NIAID NIH HHS; T32 AI07247/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Anti-HIV Agents
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Initial clinical experience using a novel laparoscopy assistant.
Next Document:  Perspective: does ranolazine have potential for the treatment of atrial fibrillation?