| Short communication: dynamic constraints on the second phase compartment of HIV-infected cells. | |
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MedLine Citation:
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PMID: 21105850 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The cells responsible for the second phase decay of HIV-1 viremia following the initiation of antiretroviral therapy have yet to be identified. A dynamic model that considers where drugs act in the virus life cycle places constraints on candidate cell types. In this regard, the rapid drop in viremia in patients starting regimens containing the integrase inhibitor raltegravir is of particular interest. We show here that the time delay between reverse transcription and integration is short in differentiated macrophages, making these cells poor candidates for the second phase compartment under the assumptions of standard models of viral dynamics. |
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Authors:
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Adam M Spivak; S Alireza Rabi; Moira A McMahon; Liang Shan; Ahmad R Sedaghat; Claus O Wilke; Robert F Siliciano |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-01-15 |
Journal Detail:
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Title: AIDS research and human retroviruses Volume: 27 ISSN: 1931-8405 ISO Abbreviation: AIDS Res. Hum. Retroviruses Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-06-28 Completed Date: 2011-10-12 Revised Date: 2012-09-20 |
Medline Journal Info:
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Nlm Unique ID: 8709376 Medline TA: AIDS Res Hum Retroviruses Country: United States |
Other Details:
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Languages: eng Pagination: 759-61 Citation Subset: IM; X |
Affiliation:
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Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21218, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-HIV Agents
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pharmacology* HIV Infections / drug therapy, virology* HIV-1 / drug effects*, pathogenicity* Humans Macrophages / virology* Virus Latency / drug effects* |
| Grant Support | |
ID/Acronym/Agency:
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AI081600/AI/NIAID NIH HHS; AI51178/AI/NIAID NIH HHS; T32 AI007291/AI/NIAID NIH HHS; T32 AI07247/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-HIV Agents |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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