| Dynamic chromosome organization and protein localization coordinate the regulatory circuitry that drives the bacterial cell cycle. | |
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MedLine Citation:
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PMID: 19687139 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The bacterial cell has less internal structure and genetic complexity than cells of eukaryotic organisms, yet it is a highly organized system that uses both temporal and spatial cues to drive its cell cycle. Key insights into bacterial regulatory programs that orchestrate cell cycle progression have come from studies of Caulobacter crescentus, a bacterium that divides asymmetrically. Three global regulatory proteins cycle out of phase with one another and drive cell cycle progression by directly controlling the expression of 200 cell-cycle-regulated genes. Exploration of this system provided insights into the evolution of regulatory circuits and the plasticity of circuit structure. The temporal expression of the modular subsystems that implement the cell cycle and asymmetric cell division is also coordinated by differential DNA methylation, regulated proteolysis, and phosphorylation signaling cascades. This control system structure has parallels to eukaryotic cell cycle control architecture. Remarkably, the transcriptional circuitry is dependent on three-dimensional dynamic deployment of key regulatory and signaling proteins. In addition, dynamically localized DNA-binding proteins ensure that DNA segregation is coupled to the timing and cellular position of the cytokinetic ring. Comparison to other organisms reveals conservation of cell cycle regulatory logic, even if regulatory proteins, themselves, are not conserved. |
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Authors:
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E D Goley; E Toro; H H McAdams; L Shapiro |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review Date: 2009-08-17 |
Journal Detail:
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Title: Cold Spring Harbor symposia on quantitative biology Volume: 74 ISSN: 1943-4456 ISO Abbreviation: Cold Spring Harb. Symp. Quant. Biol. Publication Date: 2009 |
Date Detail:
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Created Date: 2010-06-22 Completed Date: 2010-10-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1256107 Medline TA: Cold Spring Harb Symp Quant Biol Country: United States |
Other Details:
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Languages: eng Pagination: 55-64 Citation Subset: IM |
Affiliation:
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Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bacteria
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cytology,
genetics*,
metabolism* Bacterial Proteins / metabolism* Caulobacter crescentus / cytology, genetics, metabolism Cell Cycle / genetics, physiology Chromosomes, Bacterial / genetics* DNA, Bacterial / metabolism DNA-Binding Proteins / metabolism Evolution Models, Biological Transcription Factors / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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GM073011-04/GM/NIGMS NIH HHS; R01 GM51426 R24/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Bacterial Proteins; 0/CtrA protein, Caulobacter; 0/DNA, Bacterial; 0/DNA-Binding Proteins; 0/DnaA protein, Bacteria; 0/Transcription Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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